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Italy in 12 Days: 4 Recommended 12-day Itineraries to Italy

A woman tourist admires Florence from Piazzale Michelangelo's top view during her 12 days in Italy.
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  • Ella Catterall
  • From England
Rhy was amazing on the trip and made everyone feel super comfortable straight away. S...” Read More

Italy 12-day Itinerary Options

A 12-day trip to Italy offers ample time to explore its iconic landmarks and hidden gems. From the ancient ruins of Rome to the rolling hills of Tuscany, our recommended 12-day itineraries provide a perfect blend of history, culture, and natural beauty to inspire your Italian adventure. Check out some of our Italy 12 days itinerary ideas below.

Itinerary #1: Culture and Charm from Venice to Rome

Crowded Doge's Palace in Venice.
Visit Doge's Palace in Venice, the former residence of Venice's powerful doges, overlooking the breathtaking Grand Canal.
  Overview Activity Overnight
Day 1 Fly overnight to Italy Arrival  
Day 2 Explore Venice with a welcome dinner at night City sightseeing Venice
Day 3 Stroll through Venice's landmarks on a walking tour, witness the art of glassblowing in Murano, and end the day with a gondola ride and a Vivaldi concert Walking tour Venice
Day 4 Discover the Po Delta wetlands by pontoon boat, then savor lunch and stay at a vineyard hotel in Romagna. Boat tour Romagna
Day 5 Opt for a wine-infused mud treatment or explore Ravenna's Byzantine mosaics, followed by a pasta cooking class. Wine tasting Romagna
Day 6 Spend the day in the landlocked Republic of San Marino, and end the night with a wine-pairing dinner. Exploration Romagna
Day 7 Embark on a culinary adventure in Emilia, followed by a farm-to-table lunch before continuing to Florence. Food tour Florence
Day 8 Discover Florence's wonders, including the Piazza del Duomo, the Cathedral of Santa Maria del Fiore, and the Uffizi Museum. City sightseeing Florence
Day 9 Traverse southern Tuscany, then arrive in Rome for a three-night stay. Scenic drive Rome
Day 10 Explore Rome's Christian catacombs in the morning, delve into its Renaissance and Baroque beauty on a walking tour, and enjoy a leisurely afternoon. Sightseeing Rome
Day 11 Make the most out of your free day in the Eternal City. Exploration Rome
Day 12 Bid goodbye to Italy Departure  

This is the best 12-day Italy itinerary if you want to immerse yourself in the rich history, art, and cuisine of this enchanting country, starting in Venice, with its labyrinthine canals and iconic gondolas, and ending with a romantic stroll along the Tiber River in Rome. During this unforgettable adventure, you will travel to the Romagna region for a serene countryside retreat, then explore Ravenna's Byzantine mosaics or indulge in a hands-on cooking class. Visit the historic Republic of San Marino perched atop Mount Titano before diving into Emilia's culinary delights at a vocational school. Continue to Florence, the “Cradle of Renaissance”, and traverse the ancient Etruscan landscapes of southern Tuscany, before concluding your Italy tour in Rome, where you will explore ancient catacombs, Baroque churches, and the vibrant Trastevere district's culinary delights.

Itinerary #2: Italian Art, Food & Wine

Picturesque view of Lake Maggiore on a clear day in Italy.
Discover the enchanting beauty of Lake Maggiore in Italy, where serene waters and lush landscapes create the perfect escape.
An Italian meal with pizza and white wine with a view of a vineyard.
Italy is an incredible destination to enjoy a fine meal and a great view at the same time.
  Overview Activity Overnight
Day 1 Start your trip from Lake Maggiore. Arrival Lake Maggiore
Day 2 Cruise to Isola dei Pescatori, the most picturesque of the Borromean Islands. Boat trip Lake Maggiore
Day 3 Indulge in local specialties with cheese and wine tasting, a free afternoon in Stresa, and an optional visit to Isola Bella. Wine tasting Stresa
Day 4 Move to Lake Orta, visit the San Giulio island, then explore the stunning Italian Riviera along the Ligurian coast. Island exploration Italian Riviera
Day 5 Spend the full day discovering the colorful Cinque Terre. Exploration Cinque Terre
Day 6 Embark on an off-road adventure through Carrara's marble quarries, followed by a relaxing stay at a historic Tuscan villa. Relaxation Tuscan 
Day 7 Immerse yourself in the heart of Chianti with a hands-on cooking lesson at a family-owned villa, followed by a visit to San Gimignano. Cooking class Tuscan 
Day 8 Explore the stunning medieval town of Siena before unwinding in a quintessential Tuscan villa. Exploration Tuscan 
Day 9 Head to Florence and explore its wonders on a guided walking tour. Walking tour Florence
Day 10 Stroll through Bologna's picturesque porches before soaking up the romance of Venice for two nights. Exploration Venice
Day 11 Discover Venice's wonders—St. Mark's Square, Canal Grande, and the Murano Glass Factory—then conclude your Italian journey with a delicious dinner. Sightseeing Venice
Day 12 End your trip in Venice. Departure  

Experience the essence of Italy’s cultural and culinary delights on an unforgettable 12-day Italy tour, beginning in the serene Lake Maggiore before journeying through the Italian Riviera, exploring Stresa and beyond. Marvel at the colorful villages of Cinque Terre and venture to Carrara’s marble quarries by off-road vehicle. Enjoy a peaceful stay in a Tuscan villa, where you will get to prepare local cuisine during a hands-on cooking class and spend a rejuvenating afternoon before hitting the road again the next morning. Next, discover Florence's Renaissance marvels and Bologna’s picturesque portici, before concluding your Italy adventure in the canal city of Venice. See all culture trip packages in Italy.

Itinerary #3: Cycling from Matera to Lecce

A pair of bicycle in the beautiful coastline in Leece, Italy
Cycle through the charming streets of Lecce and immerse yourself in this hidden gem's rich history and stunning architecture.
  Overview Activity Overnight
Day 1 Arrive in Matera, the “City of Stones”. Arrival Matera
Day 2 Spend a free day exploring the UNESCO-listed Sassi of Matera. Exploration Matera
Day 3 Set off for the first cycling day, with stops in Laterza and Castellaneta. Cycling Castellaneta
Day 4 Pedal through Terra delle Gravine Natural Park, visit ancient masserie and trulli, and end the day in Putignano. Cycling Putignano
Day 5 Continue your journey through the Apulian countryside to Castellana Caves and spend the night in Alberobello. Cave exploration Alberobello
Day 6 Traverse the lush Valle d'Itria, sample local sparkling white wine, and proceed to the white city of Ostuni. Wine tasting Ostuni
Day 7 Bike through the colorful Salentinian countryside towards the medieval towns of Oria and Manduria. Cycling Manduria
Day 8 Explore Torre Colimena, then travel along the coast to Gallipoli. Cycling Gallipoli
Day 9 Reach Salento's southernmost point at Santa Maria di Leuca. Cycling Santa Maria di Leuca
Day 10 Continue cycling along the scenic Adriatic coast, exploring Grotta Zinzulusa, the hot springs of Santa Cesarea Terme, and ending in Otranto. Hot spring visit Otranto
Day 11 Follow the shoreline through olive groves to the Baroque town of Lecce Exploration Lecce
Day 12 Bid goodbye to Leece Departure  

Embark on a cycling adventure through the captivating landscapes of Italy, beginning in Matera's UNESCO World Heritage Site, known for its ancient cave dwellings, and ending in Leece, the “Florence of the South.” Pedal through olive groves, towering limestone cliffs, and Roman amphitheaters, and discover the white city of Ostuni, the majestic castle of Otranto, and the coastal gem of Gallipoli. Traverse the landscapes rich in history and natural beauty, from the hot springs of Santa Cesarea Terme to the karst formations of Castellana Caves and the picturesque Valle d'Itria. Don’t forget to experience Puglia's unique culture and cuisine, sampling local wines and indulging in traditional specialties like orecchiette con le cime di rapa, taralli, and puccia. Check out our cycling tours to Italy.

Itinerary #4: The Best of Old World Sicily & Malta

View of Saint Julian beach on a sunny day in Malta.
Spend a blissful free day on the stunning beaches of Sliema, Malta, and soak up the sun and sea during your unforgettable 12-day Italian adventure.
Cityscape image of historical centre of Syracuse with old sqaure and Syracu
Experience the magic of sunrise in Syracuse, exploring the enchanting Old Square and the majestic Syracuse Cathedral.
  Overview Activity Overnight
Day 1 Arrive in Sicily. Arrival Sicily
Day 2 Embark on a culinary tour of Scicli and Modica, savoring local flavors and exploring the picturesque towns. Food tour Modica
Day 3 Discover ancient Siracusa's archaeological treasures, then relax during a scenic drive to Taormina. Scenic drive Taormina
Day 4 Explore the charming streets of Taormina with a local guide. Exploration Taormina
Day 5 Take an off-road adventure to Mount Etna, followed by a Sicilian dinner with live music in Taormina. Road trip Taormina
Day 6 Head to the historic town of Ragusa and stroll through Ragusa-Ibla. Enjoy a free afternoon in the city and savor a peaceful countryside evening.. Exploration Ragusa
Day 7 Visit the Baroque town of Noto, known for its stunning architecture. Exploration Noto
Day 8 Journey to Palermo, the vibrant capital of Sicily. Explore its bustling markets and historic sites, and enjoy a local dinner. City sightseeing Palermo
Day 9 Fly to Malta and reach the charming resort town of Sliema. Transfer Sliema
Day 10 Set sail across Valletta’s Grand Harbour and explore the capital's highlights with a local guide. Cruise tour Sliema
Day 11 Spend a free day on the beaches of Sliema, or opt for a trip to Gozo to explore the ancient temples of Ggantija. Beach tour Sliema
Day 12 Depart from Malta Departure  

Embark on a 12-day journey through Sicily and Malta, starting in Sicily. Upon arrival, dive into a culinary tour of Scicli and Modica, savoring local delights and exploring these picturesque towns. Discover ancient Siracusa's archaeological wonders and enjoy a scenic drive to Taormina, where you'll explore its charming streets with a local guide and unwind in the afternoon. Experience an off-road adventure to Mount Etna, followed by a Sicilian dinner with live music in Taormina. Head to historic Ragusa, strolling through the enchanting Ragusa-Ibla and savoring a peaceful evening. Visit the stunning Baroque town of Noto before returning to Ragusa. Journey to Palermo to explore its vibrant markets and historic sites before flying to Malta. In Sliema, set sail across Valletta’s Grand Harbour, explore the capital's highlights, and enjoy free time on Sliema’s beaches or a trip to Gozo to see the Ggantija temples. Conclude your adventure indulging in Maltese traditions before departure.

Need help planning your 12-day itinerary to Italy?

Whether by bike, train, or foot, Italy offers countless opportunities to explore its rich tapestry of vibrant culture, timeless history, and breathtaking landscapes. Take advantage of a 12-day Italy tour to visit iconic hotspots like the Colosseum, Piazza della Signoria, and the Valley of Temples, but also carve out time to visit lesser-known gems, such as the Baroque towns of Scicli and Modica, or the stunning white city of Ostuni.

If you are looking for Italy 12 days itinerary options tailored to your preferences and interests, contact our travel experts for a customized trip to Italy. Our article on how many days to spend in Italy will also come in handy. Our articles on  11 days in Italy and 13 days in Italy will help you with the ideal duration to spend in the country. For a seasonal overview, check out our guide on the best time to visit Italy. Our guides on places to visit in Italy and things to do in Italy will also come in handy while planning a trip to Italy.

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Plan a trip to ItalyWe offer different tour types. You can also chat with a local travel specialist if you want a customized tour to Italy.
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