10 Best South America Multiday Tours in September 2026

Uyuni Salt Flats & Desert Adventure 5D/4N (La Paz to La Paz) - September 2026

(2 reviews )

No booking fees

Best price guaranteed

Embark on a captivating expedition through Uyuni’s mesmerising landscapes, including the enchanting Train Cemetery, dazzling salt flats, vibrant lagoons, and striking geologic formations. Witness spectacular wildlife like flamingos, relax in soothing thermal waters, and spend immersive nights in the singular salt hotel and a remote hostel. This journey promises a blend of natural wonders and cultural richness, offering an unforgettable experience.

Adventure

Tour Type

Small Group Tour

Accommodation

Hotel, Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

La Paz, Uyuni, Candelaria, Polques

Duration5 days

From

USD 480

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Deserts, Jungle and Wine - September 2026

(14 reviews )

Trip customizable

Best price guaranteed

The team really put together a great itinerary that takes you to meet the natural beauty of Argentina. Our adventure through the Humahuaca Gorge was an absolute highlight. The stunning landscapes and vibrant colors of the mountains left me in awe. The serenity of the Andes, the crystal-clear mountain lakes, and the rugged terrain all combined to create a truly remarkable experience. The Tango show and dinner experience was truly the cherry on top of our time in Buenos Aires. It was an emotional journey into the heart and soul of Argentina, a performance that left us spellbound and filled with appreciation for the country's culture. I can't thank enough the team for the memories I've made.

Natural landmarks sightseeing

Tour Type

Private Tour

Accommodation

Hotel, Resort

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

Buenos Aires, Mendoza, Salta, Pu

Buenos Aires, Mendoza, Salta, Purmamarca, Calchaquies Valley, Humahuaca, Calchaqui Valley

Duration12 days

From

USD 5,560

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Easter Island Experience 4D/3N - September 2026

(1 review )

No booking fees

Best price guaranteed

Discover the ancient wonders of Easter Island with an immersive adventure that showcases iconic moai statues, volcanic landscapes, and rich cultural heritage. Embark on guided tours to Rano Raraku, Orongo Ceremonial Village, and Anakena Beach, uncovering the mysteries of this remote Pacific island. Enjoy unique encounters with local traditions, folklore, and breathtaking natural beauty. This unforgettable journey offers a perfect blend of history, stunning vistas, and authentic experiences, making it a must-visit for travel enthusiasts seeking extraordinary destinations.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Easter Island, Ahu Akivi, Anaken

Easter Island, Ahu Akivi, Anakena Beach, Orongo, Hanga Roa

Duration4 days

From

USD 1,044

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Costa Rica Adventure: Volcanoes, Jungles and Beaches - September 2026

(10 reviews )

Trip customizable

Best price guaranteed

I wanted to start by saying thank you so much for such a thorough, comprehensive plan for our stay in your lovely country. From the start of working with you, I felt as though everything was covered. Your itinerary to us was easy to read, easy to share, and filled with enough information to get us excited about the visit. Then, the pacing of the entire trip seemed to be a perfect fit for my family. I already foresee us returning to experience Costa Rica again, based solely on the trip you crafted for us. We are quite grateful.

AdventureNational parks

Tour Type

Group Tour

Accommodation

Hotel, Resort

Age Range

12-65 yrs

Operated in

english

Destinations

Manuel Antonio National Park, La

Manuel Antonio National Park, La Fortuna, Monteverde Cloud Forest Biological Preserve, San Jose, Arenal, Arenal Volcano, Monteverde, Manuel Antonio, Juan Santamaria

Duration9 days

From

USD 2,260

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Tango, Wine & Blue water dreams - September 2026

(13 reviews )

Trip customizable

Best price guaranteed

Nearly all of the guides were wonderful. I don’t remember the name of the guide who took us to El Chaltén but we appreciated that he took us seriously as trekkers and suggested a slightly longer trek with beautiful views. We thoroughly enjoyed that trek! And we also were very happy with our guide in Tiera del Fuego. She was very lively, knowledgeable and provided us with a couple of wonderful hike and a delicious lunch. We loved all she knew about the birds, trees and geology on the area."

City sightseeing

Tour Type

Private Tour

Accommodation

Hotel, Resort

Age Range

1-79 yrs

Operated in

english, spanish

Destinations

Buenos Aires, Iguazu Falls, Mend

Buenos Aires, Iguazu Falls, Mendoza, Patagonia, San Carlos de Bariloche

Duration12 days

From

USD 3,695

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Argentina Nature Wonders - September 2026

4.5

(6 reviews )

Trip customizable

Best price guaranteed

Top notch service from this company which I chose for our Argentina trip because they're based in Buenos Aires and have a focus on South America. Clara Gonzalez crafted an experience perfectly in line with our request and did so quickly and accurately. Antonella Pascarelli provided us with the expert support we needed before and during the trip. She informed us of needed documentation, answered detailed questions about hotels and restaurants, handled all hotel stays accurately and made dinner reservations at our choice of restaurants. Land transfers were crucial to our moving about the country and the app included necessary information about that. The guides (Diana in Buenos Aires; Shoam in El Chalten) were both well informed, efficient and personable. I'm glad Antonella knew which companies with whom to work. When we were in country, I received daily emails from Antonella checking in on how things were going and making sure we were on track with the next phase of the trip. I would like to return to South America and I will most certainly try to work with with them.

City sightseeing

Tour Type

Private Tour

Accommodation

Hotel, Tent

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

Buenos Aires, Patagonia, Perito

Buenos Aires, Patagonia, Perito Moreno Glacier, Iguazu Falls, Ushuaia, Beagle Channel Cruise, El Calafate

Duration12 days

From

USD 3,060

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Peru: Inca Jungle & Rainbow Mountain Trek - September 2026

32% OFF TODAY

Super Sales

Peru: Inca Jungle & Rainbow Mountain Trek - September 2026

(8 reviews )

No booking fees

Best price guaranteed

I had an absolute blast on this trip with GAdventures. This trip provided the perfect amount of included activities and action that I was looking for in a trip. Our CEO Joseph was also greatly knowledgeable about the area and the history, adding to the overall experience.

Rainforest and jungle visits

Tour Type

Small Group Tour

Accommodation

Hotel, Hostel

Age Range

18-39 yrs

Operated in

english

Destinations

Cusco, Santa Teresa, Aguas Calientes

32% OFF TODAY

Duration7 days

From

USD 999

USD 678

Saving

USD 321

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The Total Peru Package: Cities, Deserts & Inca Ruins - September 2026

27% OFF TODAY

Super Sales

The Total Peru Package: Cities, Deserts & Inca Ruins - September 2026

(7 reviews )

No booking fees

Best price guaranteed

Thanks to Sergio, we had the best time on this trip. Jam packed but still found time to do what we wanted to achieve. Had a blast. Would totally recommend to people. ROAMIES is a great idea.

City sightseeing

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel, Hut

Age Range

18-35 yrs

Operated in

english

Destinations

Cusco, Lima, Huacachina, Ollanta

Cusco, Lima, Huacachina, Ollantaytambo, Aguas Calientes

27% OFF TODAY

Duration11 days

From

USD 1,429

USD 1,039

Saving

USD 390

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Inca Trail to Machu Picchu 4 days with Vistadome Train - September 2026

(8 reviews )

Trip customizable

Best price guaranteed

As our guide would say "The point is this, my friends"... and the day begins. This was one of the best experience I have had. Our guide - Gary - made sure we were on schedule on the trek. He explained to us all the pros and cons and how to get the most out of the Inca Trail. The porters were great. The chef - Julio - made the best camp meals for vegetarians. The scenery is breathtaking. Yes it may seem long and a lot of walking but its worth it. The team made the whole journey worthwhile - from booking to the end. Rosmel - our booking contact kept us informed all the time. Don't hesitate, just do it. Great guide, chef and company. Mahesh

Trekking and HikingAdventure

Tour Type

Small Group Tour

Accommodation

Camping, Hotel, Tent

Age Range

1-75 yrs

Operated in

english, spanish

Destinations

Machu Picchu, Ayapata District

Machu Picchu, Ayapata District, Chaquicocha, Wiñay Wayna, Cusco

Duration4 days

From

USD 800

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Treasures of Patagonia - September 2026

(7 reviews )

Trip customizable

Best price guaranteed

All in great company and superbly organised. I was travelling solo and the guide and group made me feel hugely welcome.

Active and outdoor

Tour Type

Private Tour

Accommodation

Hotel, Tent, Camping

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

El Calafate, El Chalten, Patagon

El Calafate, El Chalten, Patagonia, Perito Moreno Glacier

Duration6 days

From

USD 2,485

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Super Sales

Quito to La Paz: Amazon & Ancient Cultures - September 2026

(8 reviews )

No booking fees

Best price guaranteed

Really nice experience, I saw a lot things and had many highlights. It was a pitty that our first CEO was not that good and caused some negative vibes in the group. The Lares Trek was cool and no problem at all for me regarding the hike but some people should have not be on the trek because they struggled really hard and we needed to wait really long for them.

Trekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge, Hut, Home-stay, Camping, Hostel

Age Range

18-39 yrs

Operated in

english

Destinations

Quito, La Paz, Mancora, Trujillo

Quito, La Paz, Mancora, Trujillo, Lima, Huacachina, Nazca, Arequipa, Tena, Cusco, Ollantaytambo, Inca Trail, Puno, Lake Titicaca, Banos, Cuenca

Duration35 days

From

USD 4,599

USD 4,461

Saving

USD 138

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Buenos Aires, Ushuaia and El Calafate - September 2026

4.5

(2 reviews )

No booking fees

Best price guaranteed

Really good tour of Buenos Aires city and Patagonia in Argentina. I highly recommend doing it, you wont regret!

Active and outdoor

Tour Type

Group Tour

Accommodation

Hotel

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

Buenos Aires, El Calafate, Ushua

Buenos Aires, El Calafate, Ushuaia, Perito Moreno Glacier, Buenos Aires

Duration10 days

From

USD 2,090

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Costa Rica Family Vacation - September 2026

(6 reviews )

Trip customizable

Best price guaranteed

Excellent guides, well planned, prompt and professionals

VolcanoesNational parksBeach

Tour Type

Private Tour

Accommodation

Hotel

Age Range

2-79 yrs

Operated in

English

Destinations

San Jose, Arenal Volcano, Nicoya

San Jose, Arenal Volcano, Nicoya Peninsula, La Fortuna

Duration6 days

From

USD 1,624

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Puerto Maldonado Amazon Eco-Lodge 4D/3N (from Puerto Maldonado) - September 2026

(2 reviews )

No booking fees

Best price guaranteed

A unique experience all arouns. Fished for piranhas, saw pink dolphins and was amazed by nature's wonders. This was the most authentic trip i've ever done. Special thanks to our bamba guide!

Rainforest and jungle visits

Tour Type

Small Group Tour

Accommodation

Lodge, Bungalow, Eco Lodge, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Puerto Maldonado, Amazon Lodge Tambopata

Duration4 days

From

USD 607

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All South America Tours in September 2026

Page 7 of 320 Trips in South America during September 2026 with 831 Reviews

Page 7 of 320 Trips in South America during September 2026 with 831 Reviews

Uyuni Salt Flats & Desert Adventure 5D/4N (La Paz to La Paz) - September 2026

Deserts, Jungle and Wine - September 2026

Easter Island Experience 4D/3N - September 2026

Costa Rica Adventure: Volcanoes, Jungles and Beaches - September 2026

Tango, Wine & Blue water dreams - September 2026

Argentina Nature Wonders - September 2026

Peru: Inca Jungle & Rainbow Mountain Trek - September 2026

The Total Peru Package: Cities, Deserts & Inca Ruins - September 2026

Inca Trail to Machu Picchu 4 days with Vistadome Train - September 2026

Treasures of Patagonia - September 2026

Quito to La Paz: Amazon & Ancient Cultures - September 2026

Buenos Aires, Ushuaia and El Calafate - September 2026

Costa Rica Family Vacation - September 2026

Puerto Maldonado Amazon Eco-Lodge 4D/3N (from Puerto Maldonado) - September 2026

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Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All South America Tours in September 2026

Page 7 of 320 Trips in South America during September 2026 with 831 Reviews

Page 7 of 320 Trips in South America during September 2026 with 831 Reviews