10 Best Santiago Multiday Tours in September 2026

Atacama & the North - 10 Days - September 2026

No booking fees

Best price guaranteed

Get off the beaten track in Chile’s northern reaches with this unique adventure through the Atacama Desert. Kicking off in Santiago discover fascinating museums, lunar-like landscapes of geysers and rock formations, pre-Hispanic ruins and gigantic geoglyphs, mammoth copper mines and abandoned ghost towns with plenty of natural beauty to boot.

Art and architecture

Tour Type

Private Tour

Accommodation

Hotel

Age Range

18-80 yrs

Operated in

english

Destinations

Santiago, Arica, San Pedro De At

Santiago, Arica, San Pedro De Atacama, Atacama Desert, El Tatio, Iquique, Putre

Duration10 days

From

USD 7,015

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Grand South America - September 2026

(1 review )

No booking fees

Best price guaranteed

was a great tour director made sure about everyone needs

City sightseeing

Tour Type

Group Tour

Accommodation

Hotel, Resort

Age Range

5-99 yrs

Operated in

english

Destinations

Rio de Janeiro, Lima, Lake Titic

Rio de Janeiro, Lima, Lake Titicaca, Santiago, Valparaiso, Buenos Aires, Pampas, Iguassu National Park, Iguassu National Park, Cusco, Sacred Valley, Machu Picchu, Puno

Duration23 days

From

USD 16,821

USD 16,316

Saving

USD 505

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Premium Highlights of South America - September 2026

No booking fees

Best price guaranteed

Experience the diversity of wonders across Peru, Chile, Argentina and Brazil on a 24-day Premium journey. Be immersed in the ancient culture of the Incas, visit the Amazon Jungle and revel in the magnificent citadel ruins of Machu Picchu. Soak up the energy of Santiago and Buenos Aires’ lively neighbourhoods and sip some of the world’s best wine in Mendoza. At the border with Brazil, experience the magnificent might of Iguazu Falls, before finally arriving in one of the most beautiful cities in the world, Rio de Janeiro. With the guidance of passionate local leaders, you’ll find out South America dances to the beat of its own drum.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge, Resort

Age Range

15-99 yrs

Operated in

english

Destinations

Rio de Janeiro, Lima, Santiago

Rio de Janeiro, Lima, Santiago, Valparaiso, Mendoza, Buenos Aires, Puerto Maldonado, Puerto Iguazu, Amazon Lodge Tambopata, Cusco, Ollantaytambo, Machu Picchu

Duration24 days

From

USD 15,815

USD 15,341

Saving

USD 474

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Cartagena To Rio (19 Weeks) Kingdoms & Carnivals - September 2026

No booking fees

Best price guaranteed

Explore the very best that this part of the world has to offer with a trip which takes you all the way from densely bio-diverse Colombia all the way to the Brazilian capital. This trip has something for everyone and offers a real taste of all the different facets that South America has to offer. Along the way pay a visit to Ushuaia, the southernmost city in the world, take in the cultural diversity and extremes of climate that spanning 7 countries will inevitably showcase and see both extremes of city immersion and real remoteness. While there will be long drives and tough camping and cooking conditions this tour gives you a unique opportunity to see the real South America and the possibility to meet people you would never otherwise encounter. Our journey ends in Rio, where you will have the chance to join in the world-renowned festivities of Carnival or New Year's Eve celebrations. Please note that the accommodation on this trip is predominantly camping, though there may be opportunities to upgrade this locally where rooms are available. Please see the trip inclusions for an approximate percentage of camping and room nights

Overland Journeys

Tour Type

Group Tour

Accommodation

Camping, Resort, Lodge

Age Range

12-85 yrs

Operated in

english

Destinations

Rio de Janeiro, Cartagena, Tayro

Rio de Janeiro, Cartagena, Tayrona National Park, Uyuni, Salta, Santiago, El Chaltén, Torres del Paine National Park, Ushuaia, Buenos Aires, Iguazu Falls, Bogota, Pantanal, Parque Purac, Quito, Amazon Ecuador, Lima, Colca Canyon, Machu Picchu, La Paz

Duration135 days

From

USD 8,628

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Patagonian Explorer Cruise - September 2026

Trip customizable

Best price guaranteed

This land and cruise tour will take you to see the marvels of two iconic South American cities and to the Fjords of Tierra del Fuego in Patagonia. Start this adventure in Santiago, a beautiful cosmopolitan city where you will see Santiago’s most important sites like Plaza de Armas, Modena Palace, Santa Lucía Hill and Barrio Lastarria, the latest is famous for the cultural, inherited and gastronomical options. Continue to Punta Arenas from where you will board your cruise to explore Patagonia. During this cruise you will see the fjords of the southern edge of Tierra del Fuego. Sail the Strait of Magellan into the labyrinth of channels from where you will see the highlights and most important sites and glaciers of the region, you will also visit Wulaia Bay and Cape Horn, known as the “End of the Earth”. After this wonderful cruise in Patagonia, you will disembark in Ushuaia from where you will fly to your last stop, Buenos Aires where you’ll have the chance to explore many of the city’s intriguing and varied neighbourhoods and learn about their culture and history before your tour ends.

CruiseCity sightseeing

Tour Type

Independent Tour

Accommodation

Hotel, Ship Cabin

Age Range

8-99 yrs

Operated in

English

Destinations

Buenos Aires, Punta Arenas, Ushu

Buenos Aires, Punta Arenas, Ushuaia, Wulaia Bay, Pia Glacier, Cóndor Glacier, Santiago

Duration6 days

From

USD 3,097

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Santiago to Patagonia - 14 days - September 2026

No booking fees

Best price guaranteed

Discover Chile in all its glorious natural beauty from the glittering lakes of Puerto Varas, the scenic archipelago of Chiloé, the panoramic views from Punta Arenas and the jagged granite peaks of the Paine massif. Along the way visit traditional fishing villages, observe comical penguins and explore Torres del Paine national park in your way.

Sightseeing ToursWaterfalls

Tour Type

Private Tour

Accommodation

Hotel

Age Range

18-80 yrs

Operated in

english

Destinations

Santiago, Punta Arenas, Torres D

Santiago, Punta Arenas, Torres Del Paine, Puerto Varas, Peulla, Chiloe National Park, Santiago

Duration14 days

From

USD 7,795

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Premium Peru, Chile & Argentina - September 2026

No booking fees

Best price guaranteed

Capture the true essence of South America on an 18-day Premium adventure through Peru, Chile and Argentina. This journey showcases the continent’s diversity of natural beauty, historic wonder and world-class cuisine, passing by the Andes and the Amazon, Mendoza and the majestic Machu Picchu, the Sacred Valley and sultry Santiago, all the way to the Argentinian powerhouse of Buenos Aires. Gain an insight into ancient Inca culture and local communities, indulge in fine food and some of the region’s best wine, and get to the heart of each destination with expert local knowledge at every step.

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge, Resort

Age Range

15-99 yrs

Operated in

english

Destinations

Buenos Aires, Lima, Santiago, Va

Buenos Aires, Lima, Santiago, Valparaiso, Mendoza, Amazon Jungle, Cusco, Ollantaytambo, Machu Picchu

Duration18 days

From

USD 11,170

USD 10,835

Saving

USD 335

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Premium Chile & Argentina - September 2026

18% OFF TODAY

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Premium Chile & Argentina - September 2026

No booking fees

Best price guaranteed

Against the magnificent backdrop of the Andes Mountains, journey from Santiago to Buenos Aires, taking in all the history, culture and cuisine in between. This nine-day Premium adventure will show you the heart of Chile and Argentina as you stroll the streets of Santiago with a local guide and sip piscos on a rooftop in the historic centre of Valparaiso. Sample some of the world’s best wine in Mendoza, stroll the stylish neighbourhoods of Buenos Aires and discover El Tigre Delta for an adventure to remember. Packed with Exclusive Experiences, historical Feature Stays and with a local leader by your side, you’ll fall for the vibrancy and indulgent atmosphere of this part of the world in no time.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

15-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Valparai

Buenos Aires, Santiago, Valparaiso, Mendoza

18% OFF TODAY

Duration9 days

From

USD 6,135

USD 5,059

Saving

USD 1,076

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Santiago to Buenos Aires: Volcanos, Valleys & the Lake District - September 2026

No booking fees

Best price guaranteed

Pack your bags and get ready to bounce through South America on this 12-day ride full of wild nature, epic nights, and laid-back lake vibes. Start in Santiago and hop an overnight bus to Pucón, where volcanoes, hot springs, and endless adventure await. Cruise through Chile’s dreamy Lake District with a chill stop in Puerto Varas, then cross into Argentina to explore the outdoorsy paradise of Bariloche. Hike, bike, or just soak it all in — your pace, your way. Wrap things up in buzzing Buenos Aires with tango, steak, and one last big night out. This is South America in full colour, and you’re living it large.

Explorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-39 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Pucon, P

Buenos Aires, Santiago, Pucon, Puerto Varas, San Carlos de Bariloche

Duration12 days

From

USD 1,599

USD 1,551

Saving

USD 48

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15% OFF TODAY

Essential Colombia to Chile - 21 days - September 2026

No booking fees

Best price guaranteed

GROUP TOUR (FOR AGES 18 - 55): Set out on the ultimate South American journey with this 21 day tour, packed with bucket-list experiences, breathtaking landscapes, and thrilling adventures! Take in Medellin and Bogota, trek through the Andes to the legendary Machu Picchu, take a boat ride on Lake Titicaca, and explore the vibrant streets of La Paz. Cross the otherworldly Uyuni Salt Flats in a 4x4, marvel at flamingo-filled lagoons, and soak in high-altitude hot springs. Finally, chase adrenaline in the Atacama Desert, from cycling in the Lunar Valley to stargazing under one of the clearest night skies on Earth.

Explorer

Tour Type

Group Tour

Accommodation

Camping, Guest House, Hostel, Hotel, Sleeper Bus

Age Range

18-55 yrs

Operated in

english

Destinations

Medellin, Santiago, Machu Picchu

Medellin, Santiago, Machu Picchu, Cusco, Puno, La Paz, Uyuni, San Pedro De Atacama, Santiago, Salento, Cali, Bogota, Inca Trail

15% OFF TODAY

Duration21 days

From

USD 9,145

USD 7,773

Saving

USD 1,372

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Picturesque Solo Chile Tour - September 2026

Trip customizable

Best price guaranteed

ABOUT THIS TRIP This small-group tour of Chile will show you the most exhilarating sites and breathtaking attractions this country has to offer! From cosmopolitan cities to magnificent deserts, you will fall in love with the beauty and magic of Chile. Begin your tour in Santiago, the capital which is famous for its magnificent mountain views. Learn about the history and culture of the city as you visit the Plaza de Armas and Santa Lucia Hill. Catch a flight to Punta Arenas, from where you will travel to Puerto Natales. Discover the extraordinary beauty of the region as you explore Patagonia with its magnificent mountains, fjords, glaciers, forests, and steppes. From there you will fly to the Atacama and discover the driest desert in the world as you explore the Moon Valley. This is a breathtaking geological wonder which will make you feel like you are walking on the moon! Bask in the beauty of the Andes Mountains and the teeming volcanoes in this otherworldly area, where you will end your tour of Chile. This is a Solo Tour You don't pay single supplement and get a room for yourself!

Explorer

Tour Type

Group Tour

Accommodation

Hotel, Villa

Age Range

8-99 yrs

Operated in

english

Destinations

Santiago, Atacama Desert, San Pe

Santiago, Atacama Desert, San Pedro De Atacama, Puerto Natales

Duration10 days

From

USD 2,834

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South America Discovery: Lima To Rio De Janiero - September 2026

22% OFF TODAY

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South America Discovery: Lima to Rio de Janiero - September 2026

No booking fees

Best price guaranteed

Get ready for the adventure of a lifetime with this 38-day journey through five incredible South American countries — a dream for history buffs, nature enthusiasts, and nightlife seekers alike. Ride the rails through Peru’s stunning Urubamba Valley to the iconic Machu Picchu, dive into the vibrant culture of Lake Titicaca, and marvel at the surreal landscapes of Bolivia’s Salar de Uyuni and Chile’s Valley of the Moon in the Atacama Desert. Explore colorful Valparaíso, find thrills in the adventure haven of Pucón, and relax in the lakeside charm of Bariloche. From the tango halls of Buenos Aires to the samba beats of Rio de Janeiro, and the thundering majesty of Iguassu Falls, every moment of this trip will leave you in awe and hungry for more.

Explorer

Tour Type

Small Group Tour

Accommodation

Guest House, Hotel, Resort

Age Range

12-100 yrs

Operated in

english

Destinations

Rio de Janeiro, Lima, La Paz, Su

Rio de Janeiro, Lima, La Paz, Sucre, Potosi, Uyuni, Salt Flats, San Pedro De Atacama, Cusco, Santiago, Valparaiso, Pucon, San Carlos de Bariloche, Buenos Aires, Foz Do Iguacu, Paraty, Ilha Grande, Ollantaytambo, Aguas Calientes, Puno

22% OFF TODAY

Duration38 days

From

USD 9,499

USD 7,371

Saving

USD 2,128

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10% OFF TODAY

Essential South America featuring Chile, the Mendoza Wine Region & Buenos Aires - September 2026

No booking fees

Best price guaranteed

Experience the essence of two South American countries on a comprehensive journey from Santiago, Chile to Argentina’s wine country and vibrant Buenos Aires. Stroll through Santiago’s Central Market, picking up fresh ingredients to incorporate in a seafood lunch. Spend two nights in Mendoza, South America’s famous wine country. Discover the rhythm of Buenos Aires and learn to tango with the best. In the Pampas of Argentina, explore gaucho culture and spend a day on a traditional estancia. Encounter the history and culture of Chile and Argentina in capital cities and the sprawling countryside.

Cultural, religious and historic sites

Tour Type

Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Mendoza

10% OFF TODAY

Duration10 days

From

USD 4,099

USD 3,699

Saving

USD 400

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Andean Discovery - 18 days - September 2026

No booking fees

Best price guaranteed

Discover the highlights of Chile, Bolivia and Argentina on this 18 day private tour, visiting Atacama and the otherworldly Valley of the Moon, Uyuni, the world's largest salt flat and the spectacular Iguazu Falls, before ending in the sultry capital of Buenos Aires.

Explorer

Tour Type

Private Tour

Accommodation

Hotel, Villa

Age Range

18-80 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Santiago

Buenos Aires, Santiago, Santiago, Tupiza, Purmamarca, Salta, Iguazu Falls, San Pedro De Atacama, Laguna Colorada, Uyuni

Duration18 days

From

USD 7,805

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All Santiago Tours in September 2026

Page 3 of 46 Trips in Santiago during September 2026 with 61 Reviews

Page 3 of 46 Trips in Santiago during September 2026 with 61 Reviews

Atacama & the North - 10 Days - September 2026

Grand South America - September 2026

Premium Highlights of South America - September 2026

Cartagena To Rio (19 Weeks) Kingdoms & Carnivals - September 2026

Patagonian Explorer Cruise - September 2026

Santiago to Patagonia - 14 days - September 2026

Premium Peru, Chile & Argentina - September 2026

Premium Chile & Argentina - September 2026

Santiago to Buenos Aires: Volcanos, Valleys & the Lake District - September 2026

Essential Colombia to Chile - 21 days - September 2026

Picturesque Solo Chile Tour - September 2026

South America Discovery: Lima to Rio de Janiero - September 2026

Essential South America featuring Chile, the Mendoza Wine Region & Buenos Aires - September 2026

Andean Discovery - 18 days - September 2026

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Santiago Tours in September 2026

Page 3 of 46 Trips in Santiago during September 2026 with 61 Reviews

Page 3 of 46 Trips in Santiago during September 2026 with 61 Reviews