10 Best Santa Cruz Multiday Tours in October 2025

Marion PassierTravel Expert in Ecuador
Alejandro JacomeTravel Expert in Colombia & Ecuador
Maria SzlafszteinTravel Expert in Argentina, Bolivia, Brazil, Chile, Ecuador, Paraguay, Peru & Uruguay
Clara GonzalezTravel Expert in Argentina, Bolivia, Brazil, Chile, Ecuador, Paraguay, Peru & Uruguay

Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

Duration

5 days14 days

Day Tour
Multiday Tour

Price

USD 1,053USD 8,099

Budget Tours
Luxury Tours

Page 2 of 15 Trips in Santa Cruz during October 2025 with 22 Reviews

Showing 1 - 14 of 15 results

Start & End Location

Machu Picchu & Galapagos Wonders featuring a 4-Night Cruise - October 2025

No booking fees

Best price guaranteed

Journey from the Land of the Incas to the Galápagos archipelago, enjoying a 4-night cruise aboard a personal yacht. Delve deep into ancient cultures at Machu Picchu – the fabled lost city. Explore UNESCO-designated Spanish colonial cities and stand between two hemispheres at the Equatorial Line. Experience the best of the Galápagos archipelago, where an abundance of natural wildlife recalls Darwin’s theories in a pristine world that’s virtually unspoiled. You’ll encounter hidden wonders in Peru, the “Middle of the World” in Ecuador, and see ethereal wildlife on a cruise along Eden-like islands.

Trekking and Hiking

Tour Type

Group Tour

Accommodation

Hotel, Ship Cabin

Age Range

1-99 yrs

Operated in

english

Destinations

Lima, Santa Cruz, Quito, Isabela

Lima, Santa Cruz, Quito, Isabela Island, Isla Santiago, Sacred Valley, Machu Picchu, Cuzco

Duration14 days

From

USD 7,899

View Tour

Upcoming Departures

Oct 27

Almost sold out

Jun 29

Filling fast

All Santa Cruz Tours in October 2025

Page 2 of 15 Trips in Santa Cruz during October 2025 with 22 Reviews

Get a customized trip to Santa Cruz in October 2025

Page 2 of 15 Trips in Santa Cruz during October 2025 with 22 Reviews

Machu Picchu & Galapagos Wonders featuring a 4-Night Cruise - October 2025

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Santa Cruz Tours in October 2025

Page 2 of 15 Trips in Santa Cruz during October 2025 with 22 Reviews

Get a customized trip to Santa Cruz in October 2025

Page 2 of 15 Trips in Santa Cruz during October 2025 with 22 Reviews

Machu Picchu & Galapagos Wonders featuring a 4-Night Cruise - October 2025