10 Best Andes Multiday Tours in September 2025

Atacama & Uyuni Salt Flats Adventure 7D/6N - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure through the breathtaking landscapes of the Atacama Desert and Uyuni Salt Flats. Discover awe-inspiring sights like Moon Valley, the striking Red Lagoon, and the world-renowned Uyuni Salt Flats. Experience unique activities such as stargazing in one of the clearest night skies on Earth and exploring surreal rock formations. This tour promises an immersive journey filled with natural wonders, perfect for travelers seeking extraordinary experiences in South America's most dramatic desert scenery.

Adventure

Tour Type

Small Group Tour

Accommodation

Hotel, Hostel, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Uyuni, Calama, San Pedro De Atac

Uyuni, Calama, San Pedro De Atacama, Villamar Mallcu

Duration7 days

From

USD 1,179

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Bolivia Explorer 8D/7N - September 2025

No booking fees

Best price guaranteed

Discover Bolivia's breathtaking landscapes and rich cultural heritage on this immersive adventure. Trek through awe-inspiring Andean mountains, marvel at the otherworldly Uyuni Salt Flats, explore the vibrant streets of La Paz, and uncover ancient ruins in Tiwanaku. This journey offers a perfect blend of nature, history, and local experiences, ensuring unforgettable memories. Ideal for nature enthusiasts and history buffs, this comprehensive tour highlights the must-see destinations and hidden gems of Bolivia. Experience the magic of Bolivia like never before!

AdventureWildlifeWalking tours

Tour Type

Small Group Tour

Accommodation

Hotel, Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

La Paz, La Paz, Isla Del Sol, Uy

La Paz, La Paz, Isla Del Sol, Uyuni, Atulcha, Huayllajara

Duration8 days

From

USD 1,241

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Tango Culture & the Marvels of Nature - September 2025

4.8

(13 reviews )

Trip customizable

Best price guaranteed

You took very good care of us on our trip and we thank you for that. We would recommend your company to anyone who is interested in visiting Argentina! We miss Argentina already. Our trip was fantastic and memorable so hopefully we will return soon. There were so many parts of the trip that we loved and appreciated. We liked the fact that we were picked up by someone from the airport when we arrived. Picked up for our trip to Bariloche both ways and picked up from our hotel to go back to EZE. That definitely took some stress off of our trip. Our whole trip went accordingly without any delays or mixups. The team planned everything out and it was perfect for us. Also, we appreciated the restaurant suggestions since we didn't know where good places to eat were. We loved both our hotels. Fierro had wonderful and helpful staff. They couldn't have been more helpful to us. The breakfast was always delicious. The bed was comfortable and the room was clean. In Bariloche we stayed at Cacique Inacayal Lake Hotel and it was very nice. The view from our room was breathtaking. Waking up every morning to the blue skies, lake and mountains in the background. It was amazing. The location was great since it was only a few blocks from the Town Centre. We loved all our excursions because each was different and showed us different aspects of each city. All 3 of our guides were exceptional. We loved Rodrigo's passion for Buenos Aires and showing us the history, the way of life and the beautiful sights. I wish we would've had him show us around another day too. His English was very good so it wasn't difficult listening to him explain the history of the city. In Bariloche we had Karen as our guide. Since she spoke English there was no problem understanding her. When we went to Cerro Campanario I didn't know you had to go on a ski left. I told her i was afraid of heights and not sure if I could do it. She rode with me on the lift and helped me to go up and see the amazing views. I'm so glad she did. I wouldn't have wanted to miss those spectacular views. She also introduced us to mate tea. Rodrigo explained it to us and Karen gave us a taste of it which I'm glad she did since I didn't really like it so I didn't buy any. Karen was a nice, easy going tour guide who was happy to convey her deep knowledge of the Bariloche Big Circuit area. Then we had Nicholas take us on a boat tour of the Nahuel Huapi Lake and eventually wound up on land and trekking a mile to see a beautiful waterfall. The lake views were breathtaking. Nicholas spoke 5 different languages which was very impressive. He was very knowledgeable of the area. Everything was fantastic and went very smoothly. I just wish we could've spent more time in your beautiful country. Thank you so much for a trip of a lifetime. Everybody here asks us why we picked Argentina to visit. After i show them our pictures and talk about our trip they want to visit too someday. You took very good care of us on our trip and we thank you for that. We would recommend your company to anyone who is interested in visiting Argentina!

Adventure

Tour Type

Private Tour

Accommodation

Hotel

Age Range

5-79 yrs

Operated in

english

Destinations

Buenos Aires, Iguazu Falls Natio

Buenos Aires, Iguazu Falls National Park, Patagonia, El Calafate, Iguazu Falls

Duration8 days

From

USD 2,040

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Bolivia Highlights Adventure 14D/13N - September 2025

No booking fees

Best price guaranteed

Explore Bolivia like never before with an unforgettable adventure through its most breathtaking landscapes and cultural wonders. Experience the vibrant city of La Paz, marvel at the surreal Uyuni Salt Flats, journey through the heart of the Amazon rainforest, and discover the rich history of Potosi and Sucre. Immerse yourself in local traditions, witness stunning Andean vistas, and embrace thrilling activities like trekking and wildlife spotting. Embrace the ultimate Bolivian escapade filled with unique experiences and unforgettable memories.

AdventureTrekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

La Paz, La Paz, San Juan, Huayll

La Paz, La Paz, San Juan, Huayllajara, Copacabana, Isla Del Sol

Duration14 days

From

USD 1,686

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Santiago to Ushuaia (Ruta 40) Travel Pass - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable Patagonia adventure with Bamba’s epic journey from Santiago to Ushuaia. Traverse the legendary Ruta 40, experiencing breathtaking landscapes, majestic glaciers, and lush national parks. Hike in Torres del Paine, explore the vibrant streets of Buenos Aires, and witness the awe-inspiring Perito Moreno Glacier. This expertly curated tour offers immersive cultural experiences and unparalleled natural beauty, making it perfect for adventurous travelers seeking the ultimate South American expedition. Book now for an extraordinary travel experience.

Active and outdoorAdventure

Tour Type

Group Tour

Accommodation

Hotel, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Santiago, Ushuaia, El Chalten, E

Santiago, Ushuaia, El Chalten, El Calafate, Pucon, Puerto Varas, San Carlos de Bariloche, Perito Moreno Glacier

Duration14 days

From

USD 1,562

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Salta to La Paz Salt Flats Adventure 10D/9N - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure from the vibrant culture of Salta to the mesmerizing Uyuni Salt Flats in Bolivia. This 10-day experience offers unique encounters with breathtaking Andean landscapes, ancient ruins, and indigenous villages. Highlights include traversing the awe-inspiring altiplano, marveling at surreal salt deserts, and exploring colorful lagoons teeming with flamingos. Perfect for thrill-seekers and culture enthusiasts, this tour promises an extraordinary blend of nature, history, and adventure for an unmatched South American escape.

AdventureWalking tours

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

La Paz, Salta, La Paz, San Pedro

La Paz, Salta, La Paz, San Pedro De Atacama, Uyuni

Duration10 days

From

USD 3,440

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Rio de Janeiro to Buenos Aires (via Iguazu) Travel Pass - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure from the vibrant streets of Rio de Janeiro to the cultural heart of Buenos Aires, seamlessly connecting you through the awe-inspiring Iguazu Falls. This immersive travel pass offers unique experiences like exploring Brazil's iconic Christ the Redeemer, hiking the lush rainforest, and reveling in Argentina's vibrant tango scene. Perfect for wanderlust-driven explorers, this journey promises unparalleled natural beauty, cultural richness, and thrilling activities, ensuring memories that last a lifetime. Discover South America's best-kept secrets today!

AdventureActive and outdoor

Tour Type

Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, Pu

Buenos Aires, Rio de Janeiro, Puerto Iguazu, Ilha Grande, Paraty, Sao Paulo, Foz Do Iguacu

Duration12 days

From

USD 1,172

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14 Day Trip: Galapagos & Machu Picchu - September 2025

Trip customizable

Best price guaranteed

On this 14-day guided tour trip, you will visit the highlights of both Ecuador and Peru. Experience the highlights of the City of Quito, Cotopaxi National Park, the Galapagos Islands: Santa Cruz, El Chato, Charles Darwin Station, Pinzon Island / Isabela Island, Tintoreras, and Cabo Rosa Tunnels. In Peru, you will have the opportunity to get to know the highlights of the ancient Inca civilization. Explore the city of Cusco, the Sacred Valley, the mountain of colors, and Machu Picchu. Visit Inca structures, and learn about the historic Inca settlements and their history. You will be accompanied by a guide, who will assist you with anything you need. We will also provide you with transportation, accommodation and some meals.

Trekking and HikingWildlife

Tour Type

Group Tour

Accommodation

Hotel

Age Range

5-80 yrs

Operated in

english, spanish

Destinations

Cusco, Machu Picchu, Quito, Lima

Cusco, Machu Picchu, Quito, Lima, Galapagos Islands, Santa Cruz, Sacred Valley, Cotopaxi National Park, Mitad Del Mundo, Isla Isabela, Los Túneles

Duration14 days

From

USD 3,995

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Santiago to Buenos Aires (via Mendoza) Travel Pass - September 2025

No booking fees

Best price guaranteed

Discover an unforgettable adventure from Santiago to Buenos Aires, immersing yourself in the rich culture and breathtaking landscapes of South America. Journey through the scenic Andes, savor exquisite wines in Mendoza, and experience vibrant city life in Buenos Aires. This curated travel pass offers guided tours, diverse outdoor activities, and authentic local experiences. Perfect for wine enthusiasts and adventure seekers, this tour offers the ultimate blend of nature, culture, and culinary delights. Book now for an extraordinary South American escapade!

Adventure

Tour Type

Group Tour

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Mendoza

Buenos Aires, Santiago, Mendoza, Córdoba

Duration7 days

From

USD 505

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14-Day Journey through Argentina and Brazil - September 2025

Trip customizable

Best price guaranteed

Begin your journey in captivating Buenos Aires, rich in culture and architecture. Explore El Calafate, home to the renowned Perito Moreno Glacier. Venture north to witness the breathtaking Iguazú Falls from the Brazilian side. Conclude your trip in Rio de Janeiro, where iconic landmarks await your discovery. Experience Argentina and Brazil on this 14-day adventure, with transfers, excursions, and accommodation included

AdventureCity sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, Gu

Buenos Aires, Rio de Janeiro, Guanabara Bay, El Calafate, Foz Do Iguacu, Iguassu National Park, Iguassu National Park

Duration14 days

From

USD 6,080

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15-Day Journey Across Argentina & Peru - September 2025

Trip customizable

Best price guaranteed

Begin your journey in captivating Buenos Aires, then explore El Calafate and the renowned Perito Moreno Glacier. Next, visit Lima for the Museo Larco, and journey to Machu Picchu by Vistadome train. Embark on an unforgettable adventure, with transfers, excursions, guides, and accommodations included

AdventureCity sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Cusco, Lima, Machu

Buenos Aires, Cusco, Lima, Machu Picchu, El Tigre, El Calafate, Estancia

Duration15 days

From

USD 8,358

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Samba & Tango Air-Expedition 14D/13N (from Buenos Aires) - September 2025

No booking fees

Best price guaranteed

Embark on an exhilarating South American adventure with an exclusive air-expedition that takes you from Buenos Aires to the heart of Brazil and Argentina. Experience the vibrant cultures of Samba and Tango as you explore iconic landmarks, indulge in local cuisines, and immerse yourself in rich traditions. Highlights include scenic helicopter flights over Iguazu Falls, guided tours of Rio de Janeiro, and captivating dance performances. Perfect for culture enthusiasts and thrill-seekers, this journey guarantees unforgettable memories.

AdventureWalking tours

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, Il

Buenos Aires, Rio de Janeiro, Ilha Grande, Puerto Iguazu, Foz Do Iguacu, Paraty

Duration14 days

From

USD 5,647

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Patagonia: the Ultimate Adventure - September 2025

4.8

(20 reviews )

Trip customizable

Best price guaranteed

Antonella and Helena made planning our dream Patagonia trip such a great experience! They made sure we got the best possible plans and also helped us through our visa processes which would have been impossible task without their constant support! We highly recommend letting Say Hueque plan your trip- days in Patagonia can be very hectic and having transfers, accommodations, tickets etc reserved for you makes everything a lot easier and seamless and allows you to enjoy the place without sweating the small stuff…Antonella and Helena made that possible for us! We’re so do grateful for this beautiful vacay and we’re 100% going to be back for more!!!

Sightseeing ToursAdventure

Tour Type

Private Tour

Accommodation

Hotel

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

El Calafate, Torres del Paine Na

El Calafate, Torres del Paine National Park, Perito Moreno Glacier

Duration5 days

From

USD 960

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Lake Titicaca & Isla del Sol Explorer 3D/2N (La Paz to Cuzco) - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure exploring Lake Titicaca and the enchanting Isla del Sol. This journey offers breathtaking views, rich cultural experiences, and hands-on adventures. Highlights include boat rides on the world's highest navigable lake, ancient Inca ruins, and immersive interactions with local communities. Wander through Bolivia's cultural hubs and Peru's scenic landscapes, perfect for travelers seeking both relaxation and thrilling exploration. Enhance your South American odyssey with this unique and scenic travel experience. Secure your spot now and delve into the mystical beauty of the Andes.

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Cusco, La Paz, La Paz, Isla Del Sol

Duration3 days

From

USD 155

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All Andes Tours in September 2025

131 Trips in Andes during September 2025 with 53 Reviews

131 Trips in Andes during September 2025 with 53 Reviews

Atacama & Uyuni Salt Flats Adventure 7D/6N - September 2025

Bolivia Explorer 8D/7N - September 2025

Tango Culture & the Marvels of Nature - September 2025

Bolivia Highlights Adventure 14D/13N - September 2025

Santiago to Ushuaia (Ruta 40) Travel Pass - September 2025

Salta to La Paz Salt Flats Adventure 10D/9N - September 2025

Rio de Janeiro to Buenos Aires (via Iguazu) Travel Pass - September 2025

14 Day Trip: Galapagos & Machu Picchu - September 2025

Santiago to Buenos Aires (via Mendoza) Travel Pass - September 2025

14-Day Journey through Argentina and Brazil - September 2025

15-Day Journey Across Argentina & Peru - September 2025

Samba & Tango Air-Expedition 14D/13N (from Buenos Aires) - September 2025

Patagonia: the Ultimate Adventure - September 2025

Lake Titicaca & Isla del Sol Explorer 3D/2N (La Paz to Cuzco) - September 2025

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Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Andes Tours in September 2025

131 Trips in Andes during September 2025 with 53 Reviews

131 Trips in Andes during September 2025 with 53 Reviews