Czech Republic in 10 Days: Recommended 10-day Itineraries to Czech Republic

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Czech Republic 10-Day Itinerary Options
Whether you want to wander around the culture-filled cobblestoned streets of Prague, spend a day or two in a quintessential Czech brewery, or relax in the spa town of Karlovy Vary, with 10 days in the Czech Republic, the world is your oyster.
Itinerary #1: Highlights of Czech Republic

Overview | Activity | Overnight | |
Day 1 | Begin your trip in Prague | Sightseeing | Prague |
Day 2 | Visit Prague Castle | Culture | Prague |
Day 3 | Explore the Jewish Quarter and Wenceslas Square | Culture | Prague |
Day 4 | Take a day trip to the UNESCO-listed town of Kutna Hora | History | Prague |
Day 5 | Explore the medieval castle of Cesky Krumlov | History | Prague |
Day 6 | Relax in the spa town of Karlovy Vary | Relaxation | Prague |
Day 7 | Enjoy the architecture and churches of Olomouc | Sightseeing | Olomouc |
Day 8 | Explore the culture of Brno | Sightseeing | Brno |
Day 9 | Indulge in a day trip to the breweries of Pilsen | Food & Drink | Brno |
Day 10 | Return to Prague for shopping and onward travel | Departure |
Want to see as much as possible during your 10 days in the Czech Republic? Base yourself in the capital, Prague, and spend most of the holiday doing day trips from here. Start off by exploring Prague. Hit the main sights like the engineering marvel that is the Astronomical Clock, the Charles Bridge, and the bustling Old Town Square. Journey into the historic Prague Castle, which is one of the largest castle complexes in the world. From here, explore the Mala Strana neighborhood with its Baroque architecture before journeying to the stunning Jewish Quarter with its range of museums, including the Jewish Museum. Enjoy some shopping in Wenceslas Square before taking in a show at the National Theatre. Leave Prague behind and visit the UNESCO-listed town of Kutna Hora, known for its spooky crypts like the Sedlec Ossuary and gothic churches like St. Barbara’s. Travel back in time in Southern Bohemia to Cesky Krumlov, and stroll along the Vltava River, surrounded by medieval architecture. Next, pack your bathing suit for a day in the open-air hot springs of Karlovy Vary. Follow this with a trip to the UNESCO Holy Trinity Column, in Olomouc, known for its Baroque architecture and places of worship. Journey to Czechia’s second-largest city, Brno, where you can soak up the artistic vibes and visit the 13th-century Spilberk Castle. Travel onwards to the city of Pilsen, known for its namesake Pilsner beer. Indulge in a brewery tour at the Pilsner Urquell Brewery before heading back to Prague for some last minute souvenir shopping before heading home.
Itinerary #2: Prague, Mikulov to Kroměříž

Overview | Activity | Overnight | |
Day 1 | Arrive in Prague | Sightseeing | Prague |
Day 2 | Explore the Old Town of Prague | Sightseeing | Prague |
Day 3 | Soak up the culture of the Jewish Quarter | Culture | Prague |
Day 4 | Relax and explore Karlovy Vary | Sightseeing | Karlovy Vary |
Day 5 | Tour Cesky Krumlov | Sightseeing | Cesky Krumlov |
Day 6 | Go kayaking along the Vltava River | Adventure | Cesky Krumlov |
Day 7 | Wander the medieval streets of Znojmo and go wine-tasting | Sightseeing & food & wine tour | Znojmo |
Day 8 | Explore the mountainous vineyards of Mikulov | Food & drink | Mikulov |
Day 9 | Wander the natural beauty of the Lednice-Valtice Cultural Landscape | Nature | Lednice |
Day 10 | Enjoy the chateaus of Kroměříž | Departure |
If you want a blend of historic cities, sprawling vineyards, and quaint country chateaus, you need to spend 10 days in the Czech Republic. Starting in Prague, spend the first few days exploring the Old Town, including Old Town Square, Prague Castle, and the Mala Strana neighborhood. Move onto the vibrant Jewish Quarter with its stunning 15th-century cemetery and grand synagogues. Leave the capital behind for the hot spring town of Karlovy Vary. Wander the colorful streets, soak in a natural spring, and check out the scenery that was featured in James Bond films. Move on to the town of Cesky Krumlov. This UNESCO-recognized fairytale town is full of medieval architecture, a winding river, and a gorgeous castle. Spend the next day kayaking along the Vltava River to get a new perspective on this gorgeous town. Heading to Znojmo, make sure to visit the Romanesque Rotunda of Our Lady and St. Catherine before indulging in a local wine tasting. The vineyard adventures continue in Mikulov, a stunning wine town that’s surrounded by the mighty Pálava Mountains and known for the Mikulov Chateau. Leave the towns behind and journey into the Lednice-Valtice Cultural Landscape, known as the ‘Garden of Europe’ and home to chateaus, lakes, gardens, and colonnades. Drive through the landscape and stop off at the many chateaus, including the stunning archbishop’s chateau at Kroměříž. Spend a full day here to enjoy the splendor of the gardens.
Planning a Czech Republic 10-Day Itinerary?
So if you’re planning 10 days in the Czech Republic, you have so much more than just Prague to experience. Sip delicious local wine in Znojmo, soak yourself in the hot springs of Karlovy Vary, or paddle casually down the Vltava River, surrounded by medieval architecture. If you have less time to spend in Czechia, make sure to check out our five-day itineraries for more inspiration.
Need a helping hand planning your Czech Republic trip? Our in-country travel experts are on hand to help create custom itineraries of the Czech Republic that tick all of your travel boxes.
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