10 Best South America Multiday Tours in October 2025

Cancun to San Jose Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure from Cancun to San Jose, uncovering the vibrant cultures and stunning landscapes of Central America. Experience thrilling activities like exploring ancient Mayan ruins, snorkeling in crystal-clear Caribbean waters, and hiking lush rainforests. Delight in local cuisine, lively nightlife, and charming colonial towns. This meticulously crafted travel itinerary offers unique experiences and seamless transportation, ensuring a hassle-free, exhilarating journey perfect for culture enthusiasts and natural beauty seekers. Discover the hidden gems of Mexico, Belize, Guatemala, and Costa Rica.

Trekking and HikingZip lining

Tour Type

Group Tour

Accommodation

Hostel, Home-stay, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

San Jose, Cancún, Belize City, S

San Jose, Cancún, Belize City, San Ignacio, Flores, Rio Dulce, Lanquin, Panajachel, San Jorge La Laguna, Playa Del Carmen, Antigua, Copán Ruinas, El Tunco, Leon, Granada, San Jorge, Ometepe, San Juan Del Sur, Monteverde, Manuel Antonio, Tulum, Bacalar, Chetumal, Caye Caulker

Duration39 days

From

USD 2,656

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Lima to La Paz Express Travel Pass - October 2025

No booking fees

Best price guaranteed

Discover South America's hidden gems with an unforgettable journey from Peru to Bolivia. Begin in the cultural hub of Lima, explore the enigmatic Nazca Lines, sail on majestic Lake Titicaca, and marvel at the ancient Incan city of Machu Picchu. Experience the vibrant city of Cusco and the bustling markets of La Paz. This adventure promises a blend of history, culture, and breathtaking landscapes, perfect for travelers eager to delve into the heart of the Andes.

City sightseeing

Tour Type

Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Lima, La Paz, La Paz, Arequipa

Lima, La Paz, La Paz, Arequipa, Cusco, Ballestas Islands and Paracas National Reserve, Huacachina, Colca Canyon

Duration15 days

From

USD 902

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Lima to Rio de Janeiro (via Uruguay) Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on the ultimate South American adventure with an incredible travel pass, journeying from Peru's vibrant capital to Brazil's lively Rio de Janeiro. Experience breathtaking landscapes, exotic wildlife, and rich cultural heritage. Highlights include exploring majestic Machu Picchu, tangoing in Buenos Aires, savoring Uruguayan cuisine, and basking on Rio's iconic beaches. This seamless travel pass provides an unforgettable, hassle-free way to discover the heart and soul of South America.

Trekking and HikingLagoons

Tour Type

Group Tour

Accommodation

Hotel, Hostel, Hut, Home-stay, Bungalow, Lodge, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Rio de Janeiro, Lima, Arequipa

Rio de Janeiro, Lima, Arequipa, Cuzco, Cusco, Luquina, Puno, Copacabana, La Paz, Paracas, Sucre, Potosi, Uyuni, Agencha, Polques, San Pedro De Atacama, Salta, Puerto Iguazu, Buenos Aires, Colonia Del Sacramento, Huacachina, Montevideo, Punta Del Este, Florianopolis, Sao Paulo, Paraty, Ilha Grande, Nazca, Colca Canyon

Duration53 days

From

USD 4,757

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Buenos Aires, Iguazu Falls, and self-drive in the North - October 2025

(2 reviews )

Trip customizable

Best price guaranteed

Our travel agent, Lucila, designed the best trip ever. Everything was just perfect—from the hotels to the wild experiences. We enjoyed the trip so much; every day felt like a dream. I look forward to organizing a new adventure around the world with Lucila. Everything was just AMAZING! Thank you, Lucila and team!

Self-drive or vehicle rental

Tour Type

Private Tour

Accommodation

Hotel

Age Range

12-99 yrs

Operated in

english, spanish

Destinations

Buenos Aires, Iguazu Falls, Salt

Buenos Aires, Iguazu Falls, Salta, Purmamarca, Jujuy, Humahuaca, Tilcara, Cachi, Cafayate, Puerto Iguazu

Duration18 days

From

USD 4,950

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Tour Costa Rica Fly & Drive - October 2025

Trip customizable

Best price guaranteed

With its compact size, exotic environment, unspoiled beaches, romantic culture, and wild natural landscapes, Costa Rica is the perfect destination to explore by car on a self-drive trip. This is the perfect opportunity to explore on your own with just the right amount of planned activities and free time. From San José to Manuel Antonio, drive and enjoy the most picturesque areas of the country. Visit the famous canals of Tortuguero and the beautiful beaches of the South Caribbean. Drive to the majestic Arenal Volcano, towering above the picturesque village of La Fortuna. Visit the world-famous Monteverde Cloud Forest and enjoy an included day pass of adventure activities to explore with. Finally, discover the beautiful beaches of Manuel Antonio and include a visit to the lush Manuel Antonio National Park, considered one of the most beautiful in the world thanks to the rich biodiversity of its jungle and sea coast.

Beach

Tour Type

Private Tour

Accommodation

Eco Lodge, Hotel, Lodge, Resort

Age Range

18-79 yrs

Operated in

English

Destinations

San Jose, Manuel Antonio Nationa

San Jose, Manuel Antonio National Park, Tortuguero National Park, Monteverde Cloud Forest Biological Preserve, Arenal Volcano, Cahuita National Park, Arenal Volcano National Park

Duration13 days

From

USD 2,610

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Lares Trek to Machu Picchu 4D/3N - October 2025

(12 reviews )

No booking fees

Best price guaranteed

We had an amazing time and felt well taken care of. All the gudies were so kind and helpful. I would highly recommend doing the Lares Trek with Bamba Experience.

Trekking and Hiking

Tour Type

Small Group Tour

Accommodation

Camping, Hotel, Tent

Age Range

18-99 yrs

Operated in

english

Destinations

Cusco, Machu Picchu, Lares Town

Cusco, Machu Picchu, Lares Town, Patacancha, Aguas Calientes

Duration4 days

From

USD 847

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Adventures in Patagonia + Iguazu Extension - October 2025

4.8

(6 reviews )

No booking fees

Best price guaranteed

This is a very active, fast-paced trip with plenty of opportunities for long hikes, amazing scenery and fabulous flora and fauna. Some long journeys, as it is a vast area to cover, but well worth it. An absolutely fabulous experience.

WildlifeActive and outdoor

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge

Age Range

16-79 yrs

Operated in

english

Destinations

Buenos Aires, Perito Moreno Glac

Buenos Aires, Perito Moreno Glacier, El Chaltén, Mount Fitzroy, Puerto Iguazu, Iguazu Falls, Ushuaia, Tierra Del Fuego National Park, Punta Arenas, Torres del Paine National Park, Los Glaciares National Park

Duration17 days

From

USD 7,850

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Pantanal Wildlife Experience - October 2025

Trip customizable

Best price guaranteed

There is more to Brazil than beaches and the Amazon. You don't believe it? Then join us on this 5-day, guided trip and get the chance to explore the Pantanal, which is considered a World Heritage Site by UNESCO. Well, if you take the chance to get to know this breathtaking place, you’ll understand why. Besides being the largest wetland of the world, it’s home of a diverse flora and fauna. This site offers numerous attractions and unique experiences of contact with nature, thanks to the influence of three important biomes: Amazon, Cerrado and Atlantic Forest. Located in the Brazilian states of Mato Grosso and Mato Grosso do Sul, portions of this natural wonder extend as far as Bolivia and Paraguay. Spend five days exploring this unique place with us! *With COVID-19 safety protocols*

WildlifeLocal boat rides

Tour Type

Group Tour

Accommodation

Lodge, Eco Lodge

Age Range

1-90 yrs

Operated in

english, portuguese, spanish

Destinations

Pantanal, Cuiaba, Pousada Rio Cl

Pantanal, Cuiaba, Pousada Rio Claro, Campo Grande

Duration5 days

From

USD 1,750

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One Night in Iguazu Falls - October 2025

(1 review )

No booking fees

Best price guaranteed

Enjoy a short, two-day, guided tour to discover the incredible Iguazu Falls. This itinerary includes round trip transfers from airport to hotel as well as a chance to discover the waterfall from both Argentinian and Brazilian sides. The accommodation during this trip will be in centrally located three-star hotels. The Argentinian side of the waterfall offers up to eight kilometers of trails and a chance to enjoy the waterfall from three different circuits: Upper Circuit, Lower Circuit and the Trail to the Devil`s Throat. Similarly, the Brazilian side is basically 1,500 meters of trails that offer wonderful views of the falls. Please scroll down to the itinerary section for more details.

Waterfalls

Tour Type

Group Tour

Accommodation

Hotel

Age Range

3-99 yrs

Operated in

english, portuguese, spanish

Destinations

Iguazu Falls, Puerto Iguazu

Duration2 days

From

USD 399

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Treasures of Costa Rica and Panama - October 2025

(1 review )

Trip customizable

Best price guaranteed

We loved our trip to Costa Rica/Panama and it was a perfect mix of tours and time on our own. The guides were all great and the hotels (including breakfast) all good -- one less so but not bad... Highly recommend this trip!

National parksWildlife

Tour Type

Small Group Tour

Accommodation

Hotel, Villa

Age Range

8-99 yrs

Operated in

english

Destinations

Panama City, San Jose, Panama Ca

Panama City, San Jose, Panama Canal, Soberanía National Park, Arenal, Monteverde, Manuel Antonio

Duration13 days

From

USD 2,939

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Ausangate Trek 4D/3N - October 2025

No booking fees

Best price guaranteed

Embark on a mesmerising four-day adventure through the heart of the Andes, where high-altitude lagoons, serene mountain passes, and vibrant local communities await. From the azure Ausangate peaks to the psychedelic hues of Rainbow Mountain, each day promises unparalleled exploration and cultural immersion.

Trekking and HikingExplorer

Tour Type

Small Group Tour

Accommodation

Camping, Tent, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Cusco, Ausangate, Jampa, Pacchanta

Duration4 days

From

USD 691

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Explore Tortuguero: The Amazon of Costa Rica - October 2025

Trip customizable

Best price guaranteed

Also called the Amazon of Costa Rica, Tortuguero National Park, located on the Caribbean coast, is home to a variety of wild animals and native plant species. Join us on this five-day tour of Tortuguero and soak up the rich biodiversity of this area. Exceptionally high rainfall and a unique environment where freshwater meets the sea means that Tortuguero has numerous canals, lagoons and wetlands, which you will discover during your guided boat safari and walking tour. Depending upon your arrival date, you might even get to see green sea turtles laying eggs on the beach. Please note that arrival and departure transfer is included in the tour price. However, you will have to purchase entrance tickets to Tortuguero National Park on your own. For more details, please go through the itinerary below.

Local boat ridesBeachWildlife

Tour Type

Private Tour

Accommodation

Hotel

Age Range

1-79 yrs

Operated in

english

Destinations

San Jose, Tortuguero National Park

Duration5 days

From

USD 675

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Cartagena to Bogota Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable Colombian adventure with a thrilling travel pass connecting Cartagena to Bogota. Discover vibrant street art, immerse in rich cultural history, and explore the lush Coffee Triangle's landscapes. Enjoy guided city tours, breathtaking hikes, and authentic coffee tastings. This dynamic journey combines bustling urban locales with serene natural beauty. Ideal for culture enthusiasts and nature lovers, this experience promises unique encounters and unparalleled memories. Book now for an extraordinary Colombian escapade!

Bicycle toursBeach

Tour Type

Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Bogota, Cartagena, Manizales, Sa

Bogota, Cartagena, Manizales, Santa Marta, Medellin, Hacienda Venecia Coffe Farm

Duration12 days

From

USD 1,675

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Super Sales

Quito Day Tour: Cotopaxi (full day) - October 2025

No booking fees

Best price guaranteed

Explore Cotopaxi National Park with a full-day excursion. Admire the Cotopaxi volcano and the stunning plateau on which it sits — you might even see wild horses grazing! All ages are welcome to hike the glacier, and experienced cyclists can opt to bike.

Explorer

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

14-100 yrs

Operated in

english

Destinations

Cotopaxi National Park

Duration1 day

From

USD 56

USD 54

Saving

USD 2

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All South America Tours in October 2025

Page 16 of 517 Trips in South America during October 2025 with 1,020 Reviews

Page 16 of 517 Trips in South America during October 2025 with 1,020 Reviews

Cancun to San Jose Travel Pass - October 2025

Lima to La Paz Express Travel Pass - October 2025

Lima to Rio de Janeiro (via Uruguay) Travel Pass - October 2025

Buenos Aires, Iguazu Falls, and self-drive in the North - October 2025

Tour Costa Rica Fly & Drive - October 2025

Lares Trek to Machu Picchu 4D/3N - October 2025

Adventures in Patagonia + Iguazu Extension - October 2025

Pantanal Wildlife Experience - October 2025

One Night in Iguazu Falls - October 2025

Treasures of Costa Rica and Panama - October 2025

Ausangate Trek 4D/3N - October 2025

Explore Tortuguero: The Amazon of Costa Rica - October 2025

Cartagena to Bogota Travel Pass - October 2025

Quito Day Tour: Cotopaxi (full day) - October 2025

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All South America Tours in October 2025

Page 16 of 517 Trips in South America during October 2025 with 1,020 Reviews

Page 16 of 517 Trips in South America during October 2025 with 1,020 Reviews