10 Best South America Multiday Tours in May 2027

Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

32% OFF TODAY

Super Sales

Southern Divide - May 2027

(8 reviews )

No booking fees

Best price guaranteed

Lima and Santiago bookended this trip. The small cities and towns we visited were more to my taste. La Paz was special in part because of a very good city tour largely on the cable card.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel, Resort, Guest House

Age Range

12-100 yrs

Operated in

english

Destinations

Santiago, Lima, La Paz, Sucre, P

Santiago, Lima, La Paz, Sucre, Potosi, Uyuni, Salar De Uyuni, San Pedro De Atacama, Cusco, Ollantaytambo, Aguas Calientes, Puno

32% OFF TODAY

Duration21 days

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Essential South America Featuring Chile, The Mendoza Wine Region & Buenos Aires - May 2027

27% OFF TODAY

Black Week Super Sales

Essential South America featuring Chile, the Mendoza Wine Region & Buenos Aires - May 2027

4.6

(5 reviews )

No booking fees

Best price guaranteed

Iguazu Falls and exploring the walkways and Jet Boat ride with my group on the river and getting a dunk under the falls.

Cultural, religious and historic sites

Tour Type

Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Mendoza

27% OFF TODAY

Duration10 days

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Bolivia To Peru: Lakes, Salt Flats & Machu Picchu - May 2027

18% OFF TODAY

Super Sales

Bolivia to Peru: Lakes, Salt Flats & Machu Picchu - May 2027

(4 reviews )

No booking fees

Best price guaranteed

The trip really encompassed the highlights of the 2 countries

Explorer

Tour Type

Small Group Tour

Accommodation

Camping, Home-stay, Hotel, Lodge, Bungalow, Villa

Age Range

12-100 yrs

Operated in

english

Destinations

Lima, La Paz, Puno, Lake Titicac

Lima, La Paz, Puno, Lake Titicaca, Cusco, Ollantaytambo, Inca Trail, Sucre, Potosi, Uyuni, Salt Flats

18% OFF TODAY

Duration25 days

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Black Week Super Sales

Luxury Food and Wine Tour of Argentina & Chile in 14 days - May 2027

(1 review )

Trip customizable

Best price guaranteed

Spend two weeks exploring the heart of Argentina's as well as Chile’s Southern lakes districts during this fabulous, guided tour. Enjoy the delights of Argentine and Chilean wines and gourmet food along with some of the best natural highlights of the area. Explore Buenos Aires, the 'Paris of South America', where you can enjoy an Argentine dinner along with local wines. Round it up with a stroll along Milongas. Discover Bariloche, the stunning lake region of Patagonia. Cross the Andes from Argentina to Chile enjoying amazing views of lakes, volcanoes and the majestic Andean Mountains. Learn more about the traditional gaucho way of life in San Antonio de Areco and visit ateliers and pulperias in the pampas. What are you waiting for? Book your tour today. See the itinerary for more details.

Wine tasting tours

Tour Type

Private Tour

Accommodation

Hotel

Age Range

5-79 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Mendoza

Buenos Aires, Santiago, Mendoza, Andes Mountains, Puerto Varas, Patagonia, San Carlos de Bariloche, Puerto Montt, Uco Valley, San Antonio De Areco, Pulperias, Isla Negra

Duration14 days

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32% OFF TODAY

Black Week Super Sales

Costa Rica Quest - May 2027

(14 reviews )

No booking fees

Best price guaranteed

It was a wonderful and fulfilling way to experience Costa Rica. We made amazing memories that our family will treasure forever.

Wildlife

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge

Age Range

12-100 yrs

Operated in

english

Destinations

San Jose, Manuel Antonio Nationa

San Jose, Manuel Antonio National Park, La Fortuna, Monteverde Cloud Forest Biological Preserve, Quepos

32% OFF TODAY

Duration9 days

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Black Week Super Sales

The Inca Trail - May 2027

4.8

(215 reviews )

No booking fees

Best price guaranteed

I had my doubts about doing an organised trip, but my recent Exodus experience really did change my view! Thoroughly enjoyed it.

Trekking and HikingAdventure

Tour Type

Small Group Tour

Accommodation

Hotel, Camping, Tent

Age Range

16-99 yrs

Operated in

english

Destinations

Cusco, Lima, Patallacta, Pakayma

Cusco, Lima, Patallacta, Pakaymayu, Phuyupatamarca, Aguas Calientes, Ollantaytambo, Cuzco

Duration8 days

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Black Week Super Sales

Inca Trail & the Amazon Rainforest - May 2027

4.9

(118 reviews )

No booking fees

Best price guaranteed

I was primarily interested in the Inka Trail and Machu Pichu but the rain forest and Lake Titicaca were brilliant. Three holidays in one.

Trekking and HikingAdventure

Tour Type

Small Group Tour

Accommodation

Hotel, Camping, Lodge, Home-stay, Tent

Age Range

16-99 yrs

Operated in

english

Destinations

Lima, Machu Picchu, Cusco, Puno

Lima, Machu Picchu, Cusco, Puno, Amantani Homestay, Tambopata, Inca Trail

Duration15 days

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Black Week Super Sales

Arenal Volcano & Monteverde Cloud Forest - May 2027

4.2

(11 reviews )

Trip customizable

Best price guaranteed

The weather was great! Costa Rica is great! We got adventure and relaxation. Beyond my expectations in everyway. I can't recommend enough!!

Nature and bush walks

Tour Type

Private Tour

Accommodation

Hotel, Resort

Age Range

2-79 yrs

Operated in

English

Destinations

San Jose, Monteverde Cloud Fores

San Jose, Monteverde Cloud Forest Biological Preserve, Arenal Volcano, Arenal Volcano National Park

Duration5 days

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Black Week Super Sales

The Salkantay Trek - May 2027

4.9

(62 reviews )

No booking fees

Best price guaranteed

A brilliant way to get away from it all at high altitude. Spectacular and diverse scenery.

Trekking and HikingAdventure

Tour Type

Small Group Tour

Accommodation

Hotel, Camping, Lodge, Tent

Age Range

16-99 yrs

Operated in

english

Destinations

Cusco, Lima, Machu Picchu, Ollan

Cusco, Lima, Machu Picchu, Ollantaytambo, Pumapaccha, Soraypampa, Salkantay, Pakaymayu, Phuyupatamarca

Duration14 days

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10% OFF TODAY

Black Week Super Sales

South America Samba - May 2027

(1 review )

No booking fees

Best price guaranteed

Offer more excursions

Adventure

Tour Type

Group Tour

Accommodation

Hotel

Age Range

5-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, Iguassu Falls

10% OFF TODAY

Duration9 days

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South America Tours in May 2027

Page 2 of 246 Trips in South America during May 2027 with 1,784 Reviews

Southern Divide - May 2027

Essential South America featuring Chile, the Mendoza Wine Region & Buenos Aires - May 2027

Bolivia to Peru: Lakes, Salt Flats & Machu Picchu - May 2027

Luxury Food and Wine Tour of Argentina & Chile in 14 days - May 2027

Costa Rica Quest - May 2027

The Inca Trail - May 2027

Inca Trail & the Amazon Rainforest - May 2027

Arenal Volcano & Monteverde Cloud Forest - May 2027

The Salkantay Trek - May 2027

Page 2 of 246 Trips in South America during May 2027 with 1,784 Reviews

South America Samba - May 2027

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

South America Tours in May 2027

Page 2 of 246 Trips in South America during May 2027 with 1,784 Reviews

Page 2 of 246 Trips in South America during May 2027 with 1,784 Reviews