10 Best Santiago Multiday Tours in October 2025

Santiago to Buenos Aires (via Mendoza) Travel Pass - October 2025

No booking fees

Best price guaranteed

Discover an unforgettable adventure from Santiago to Buenos Aires, immersing yourself in the rich culture and breathtaking landscapes of South America. Journey through the scenic Andes, savor exquisite wines in Mendoza, and experience vibrant city life in Buenos Aires. This curated travel pass offers guided tours, diverse outdoor activities, and authentic local experiences. Perfect for wine enthusiasts and adventure seekers, this tour offers the ultimate blend of nature, culture, and culinary delights. Book now for an extraordinary South American escapade!

Adventure

Tour Type

Group Tour

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Mendoza

Buenos Aires, Santiago, Mendoza, Córdoba

Duration7 days

From

USD 505

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Patagonian Explorer Cruise - October 2025

Trip customizable

Best price guaranteed

This land and cruise tour will take you to see the marvels of two iconic South American cities and to the Fjords of Tierra del Fuego in Patagonia. Start this adventure in Santiago, a beautiful cosmopolitan city where you will see Santiago’s most important sites like Plaza de Armas, Modena Palace, Santa Lucía Hill and Barrio Lastarria, the latest is famous for the cultural, inherited and gastronomical options. Continue to Punta Arenas from where you will board your cruise to explore Patagonia. During this cruise you will see the fjords of the southern edge of Tierra del Fuego. Sail the Strait of Magellan into the labyrinth of channels from where you will see the highlights and most important sites and glaciers of the region, you will also visit Wulaia Bay and Cape Horn, known as the “End of the Earth”. After this wonderful cruise in Patagonia, you will disembark in Ushuaia from where you will fly to your last stop, Buenos Aires where you’ll have the chance to explore many of the city’s intriguing and varied neighbourhoods and learn about their culture and history before your tour ends.

CruiseCity sightseeing

Tour Type

Independent Tour

Accommodation

Hotel, Ship Cabin

Age Range

8-99 yrs

Operated in

English

Destinations

Buenos Aires, Punta Arenas, Ushu

Buenos Aires, Punta Arenas, Ushuaia, Wulaia Bay, Pia Glacier, Cóndor Glacier, Santiago

Duration6 days

From

USD 3,097

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La Paz to Santiago Travel Pass - October 2025

No booking fees

Best price guaranteed

Discover an unforgettable adventure from La Paz to Santiago, exploring the heart of South America with unparalleled experiences. Traverse Bolivia, Peru, and Chile, diving into the vibrant cultures of each destination. This travel pass immerses you in unique activities like gazing at the Uyuni Salt Flats, exploring the Atacama Desert, and vibrant city vibes. Perfect for backpackers and culture enthusiasts seeking an authentic journey, this tour promises unforgettable memories and breathtaking landscapes. Book now for an epic South American odyssey!

Active and outdoorVolcanoes

Tour Type

Group Tour

Accommodation

Hotel, Hostel, Lodge, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Santiago, La Paz, San Pedro De A

Santiago, La Paz, San Pedro De Atacama, La Serena, Valparaiso, Sucre, Potosi, Uyuni, Agencha, Polques

Duration17 days

From

USD 1,257

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Lima to Buenos Aires (via Chile) Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on a captivating South American adventure traversing the vibrant landscapes of Lima, Santiago, and Buenos Aires. This immersive journey takes you through Peru, Chile, and Argentina, offering unique experiences such as exploring the Sacred Valley, witnessing the surreal beauty of the Atacama Desert, and savoring world-renowned Chilean wines. Discover the rich cultural heritage of each city, from Lima's historic center to Buenos Aires' tango-filled streets. Ideal for adventurers and culture enthusiasts seeking an unforgettable travel experience.

City sightseeingLocal culture

Tour Type

Group Tour

Accommodation

Hostel, Hut, Home-stay, Bungalow, Hotel, Lodge, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Lima, Arequipa, Cu

Buenos Aires, Lima, Arequipa, Cusco, Luquina, Puno, Copacabana, Paracas, La Paz, Sucre, Potosi, Uyuni, Candelaria, Polques, San Pedro De Atacama, Calama, Valparaiso, Santiago, Mendoza, Córdoba, Huacachina, Colca Canyon

Duration41 days

From

USD 2,771

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Essential Argentina And Chile - October 2025

Trip customizable

Best price guaranteed

Discover breathtaking natural wonders and famous cities with this small group tour of Argentina and Chile! Begin your journey in Buenos Aires, the capital of Argentina, to explore the bustling neighborhoods of the city and learn about the local history. Visit La Boca and walk around San Telmo, two of the most famous districts in Buenos Aires. Catch a flight to El Calafate as you cross the border into Chile and discover the Perito Moreno Glacier, one of the largest glaciers in the world. Explore the Patagonia Andean Forest and stop at the Curva de Los Suspiros known for its breathtaking views. Take the bus to Puerto Natales, a charming town with beautiful views of the southernmost peaks of the Andes Mountains, and the gateway to Torres del Paine National Park. Visit Torres del Paine National Park and discover Nordenskjold Lake with its emerald-green color. See the Balmaceda and Serrano Glaciers, travel to Punta Arenas and catch a flight to Santiago, a cosmopolitan city with historic attractions and modern splendors. Visit the Plaza de Armas and other famous attractions in this exhilarating city, where you will end your tour of Argentina and Chile.

Natural landmarks sightseeing

Tour Type

Group Tour

Accommodation

Hotel

Age Range

8-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, El Calaf

Buenos Aires, Santiago, El Calafate, Puerto Natales

Duration11 days

From

USD 2,992

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Premium Chile & Argentina - October 2025

22% OFF TODAY

Super Sales

Premium Chile & Argentina - October 2025

No booking fees

Best price guaranteed

Against the magnificent backdrop of the Andes Mountains, journey from Santiago to Buenos Aires, taking in all the history, culture and cuisine in between. This nine-day Premium adventure will show you the heart of Chile and Argentina as you stroll the streets of Santiago with a local guide and sip piscos on a rooftop in the historic centre of Valparaiso. Sample some of the world’s best wine in Mendoza, stroll the stylish neighbourhoods of Buenos Aires and discover El Tigre Delta for an adventure to remember. Packed with Exclusive Experiences, historical Feature Stays and with a local leader by your side, you’ll fall for the vibrancy and indulgent atmosphere of this part of the world in no time.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

15-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Valparai

Buenos Aires, Santiago, Valparaiso, Mendoza

22% OFF TODAY

Duration9 days

From

USD 6,145

USD 4,769

Saving

USD 1,376

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Picturesque Solo Argentina And Chile - October 2025

Trip customizable

Best price guaranteed

Explorer

Tour Type

Group Tour

Accommodation

Hotel

Age Range

8-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, El Calaf

Buenos Aires, Santiago, El Calafate, Puerto Natales

Duration11 days

From

USD 3,832

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Picturesque Solo Chile Tour - October 2025

Trip customizable

Best price guaranteed

ABOUT THIS TRIP This small-group tour of Chile will show you the most exhilarating sites and breathtaking attractions this country has to offer! From cosmopolitan cities to magnificent deserts, you will fall in love with the beauty and magic of Chile. Begin your tour in Santiago, the capital which is famous for its magnificent mountain views. Learn about the history and culture of the city as you visit the Plaza de Armas and Santa Lucia Hill. Catch a flight to Punta Arenas, from where you will travel to Puerto Natales. Discover the extraordinary beauty of the region as you explore Patagonia with its magnificent mountains, fjords, glaciers, forests, and steppes. From there you will fly to the Atacama and discover the driest desert in the world as you explore the Moon Valley. This is a breathtaking geological wonder which will make you feel like you are walking on the moon! Bask in the beauty of the Andes Mountains and the teeming volcanoes in this otherworldly area, where you will end your tour of Chile. This is a Solo Tour You don't pay single supplement and get a room for yourself!

Explorer

Tour Type

Group Tour

Accommodation

Hotel, Villa

Age Range

8-99 yrs

Operated in

english

Destinations

Santiago, Atacama Desert, San Pe

Santiago, Atacama Desert, San Pedro De Atacama, Puerto Natales

Duration10 days

From

USD 2,834

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Highlights of Chile - Atacama to Paine - October 2025

(1 review )

No booking fees

Best price guaranteed

Outdoor lovers will be in their element on this tour through some of South America's most outstanding landscapes. Chile is a land of extremes, showcasing barren desert moonscapes, dramatic granite spires and verdant farmland peppered with emerald lakes. We'll explore it all on this trip from the Atacama down to the mountains of Torres del Paine. Atacama Desert - Walk in the Moon Valley and on the Salar de Atacama Puerto Varas - Hike in Chile's Lake District, in the shadow of the Osorno Volcano Torres del Paine - Discover the glacial lakes and mountain ranges of one of the most impressive locations on earth Why not extend your trip? - Take a short stay on the mysterious Easter Island (trip code: EIE)

National parksAdventure

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

16-99 yrs

Operated in

english

Destinations

Santiago, Torres Del Paine, Puer

Santiago, Torres Del Paine, Puerto Natales, Valparaiso, Atacama Desert, Toconao, El Tatio, Calama, Osorno Volcano, Punta Arenas

Duration13 days

From

USD 6,420

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Super Sales

South America: La Paz, Santiago & the Uyuni Salt Flats - October 2025

No booking fees

Best price guaranteed

Ready to dive into the history, culture, and breathtaking wilderness of South America? Spend 11 unforgettable days exploring Bolivia and Chile, uncovering iconic highlights and hidden gems. Marvel at the surreal salt flats of the Salar de Uyuni, wander through the otherworldly desert landscapes of the Atacama Plateau, and venture off the beaten path to experience the best of this diverse region. With just the right mix of guided adventures and free time, this journey is the perfect way to truly connect with two extraordinary destinations.

Explorer

Tour Type

Small Group Tour

Accommodation

Guest House, Hotel, Resort

Age Range

12-100 yrs

Operated in

english

Destinations

Santiago, La Paz, Sucre, Potosi

Santiago, La Paz, Sucre, Potosi, Uyuni, Salt Flats, San Pedro De Atacama

Duration11 days

From

USD 2,299

USD 2,230

Saving

USD 69

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Essential South America featuring Chile, the Mendoza Wine Region & Buenos Aires - October 2025

No booking fees

Best price guaranteed

Experience the essence of two South American countries on a comprehensive journey from Santiago, Chile to Argentina’s wine country and vibrant Buenos Aires. Stroll through Santiago’s Central Market, picking up fresh ingredients to incorporate in a seafood lunch. Spend two nights in Mendoza, South America’s famous wine country. Discover the rhythm of Buenos Aires and learn to tango with the best. In the Pampas of Argentina, explore gaucho culture and spend a day on a traditional estancia. Encounter the history and culture of Chile and Argentina in capital cities and the sprawling countryside.

Cultural, religious and historic sites

Tour Type

Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Mendoza

Duration10 days

From

USD 4,099

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Buenos Aires to Santiago (via Mendoza) Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable journey from Buenos Aires to Santiago, immersing yourself in local culture and breathtaking landscapes. Enjoy wine tasting in Argentina's famed Mendoza region, marvel at the Andes’ majestic beauty, and discover vibrant cities bursting with history, art, and gastronomy. Perfect for adventure seekers and culture enthusiasts, this travel pass offers a seamless blend of city life and scenic wonders. Don't miss this chance to explore South America's most dynamic destinations.

Explorer

Tour Type

Group Tour

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Córdoba

Buenos Aires, Santiago, Córdoba, Mendoza

Duration7 days

From

USD 540

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All Santiago Tours in October 2025

Page 2 of 26 Trips in Santiago during October 2025 with 15 Reviews

Santiago to Buenos Aires (via Mendoza) Travel Pass - October 2025

Patagonian Explorer Cruise - October 2025

La Paz to Santiago Travel Pass - October 2025

Lima to Buenos Aires (via Chile) Travel Pass - October 2025

Essential Argentina And Chile - October 2025

Premium Chile & Argentina - October 2025

Picturesque Solo Argentina And Chile - October 2025

Picturesque Solo Chile Tour - October 2025

Highlights of Chile - Atacama to Paine - October 2025

South America: La Paz, Santiago & the Uyuni Salt Flats - October 2025

Essential South America featuring Chile, the Mendoza Wine Region & Buenos Aires - October 2025

Buenos Aires to Santiago (via Mendoza) Travel Pass - October 2025

Page 2 of 26 Trips in Santiago during October 2025 with 15 Reviews

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Santiago Tours in October 2025

Page 2 of 26 Trips in Santiago during October 2025 with 15 Reviews

Page 2 of 26 Trips in Santiago during October 2025 with 15 Reviews