10 Best Panama Multiday Tours in October 2025

Combine Panama in October with Nearby Countries for an Unforgettable Trip

See tours with itineraries going through multiple countries, including Panama

Alternatively, explore tours that are exclusively just Mexico and Panama, Guatemala and Panama or Costa Rica and Panama.

San Blas Chichime Islands Experience 4D/3N - October 2025

No booking fees

Best price guaranteed

Escape to a tropical paradise with an unforgettable adventure in the San Blas Chichime Islands. Revel in pristine beaches, crystal-clear waters, and vibrant marine life. Snorkel around coral reefs, interact with the indigenous Guna Yala community, and savor mouthwatering seafood. Enjoy the rustic charm of island cabins amidst swaying palms. Ideal for travelers seeking relaxation and exploration, this experience offers the perfect blend of cultural immersion and natural beauty. Discover why the San Blas Islands are a top bucket-list destination.

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 575

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Panama City Express 5D/4N - October 2025

No booking fees

Best price guaranteed

Experience the vibrant culture and stunning sights of Panama City in this unforgettable adventure. Discover the historic charm of Casco Viejo, marvel at the engineering wonder of the Panama Canal, and explore the lush biodiversity of the Rainforest Discovery Center. This immersive journey offers a perfect blend of modern city life and natural beauty, providing travelers with unique experiences and unforgettable memories. Join us for a diverse and exciting exploration of one of Central America's most captivating destinations.

AdventureWildlifeBicycle tours

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City

Duration5 days

From

USD 1,162

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San Blas Cayos Holandeses Adventure 3D/2N - October 2025

No booking fees

Best price guaranteed

Embark on a captivating San Blas adventure in the pristine Cayos Holandeses, a hidden gem in Panama. Enjoy snorkeling in crystal-clear waters, exploring remote islands, and immersing in the rich Kuna culture. Discover exotic marine life, serene beaches, and stunning sunsets that will leave you breathless. Ideal for eco-travelers and adventure seekers, this trip offers an unforgettable mix of relaxation and exploration. Book now and experience the ultimate island escape in the heart of Panama's Caribbean paradise!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration3 days

From

USD 583

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San Blas Authentic Guna Yala Experience 4D/3N - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure to the San Blas Islands, immersing yourself in the vibrant Guna Yala culture. Revel in pristine beaches, crystal-clear waters, and charming island stays. Highlights include traditional Guna crafts, snorkeling amid colorful reefs, and savoring fresh, local cuisine. Perfect for culture enthusiasts and nature lovers alike, this tour promises an authentic, off-the-beaten-path experience. Unwind in paradise and discover the untouched beauty of Panama's hidden gem. Book your ultimate island getaway now!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 432

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Welcome to Panama City 3D/2N - October 2025

No booking fees

Best price guaranteed

Embark on a captivating journey through Panama City, uniting the thrilling energy of the local culture with the historic charm of Casco Viejo. From the moment you arrive, immerse yourself in the tales of ancient streets, the beauty of striking architecture, and the stories of the past that shape today. This three-day jaunt promises a delightful blend of exploration, discovery, and leisure, enveloped within breathtaking sights and vibrant histories.

Explorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City

Duration3 days

From

USD 213

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San Blas Chichime Islands Experience 3D/2N - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable island adventure with pristine beaches, crystal-clear waters, and vibrant indigenous culture. Discover the natural beauty of the San Blas Chichime Islands, where you can snorkel among colorful coral reefs, savor fresh seafood, and immerse yourself in the laid-back Kuna lifestyle. Perfect for nature lovers and culture enthusiasts, this tropical getaway promises breathtaking sunsets, starry nights, and endless relaxation. Book your San Blas Island escape today for an authentic Caribbean experience.

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration3 days

From

USD 458

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San Blas Yanis Island Budget Experience 4D/3N - October 2025

No booking fees

Best price guaranteed

Embark on a captivating journey from the bustling streets of Panama City to the secluded serenity of the San Blas Islands. Traverse lush jungles, immerse yourself in pristine waters, and explore idyllic islands. This tropical adventure promises tranquillity and natural beauty, from coral reefs to vibrant sunsets.

Adventure

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 421

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Panama North to South Adventure 6D/5N - October 2025

No booking fees

Best price guaranteed

Discover the ultimate Panama adventure tour, immersing yourself in vibrant cultures, stunning landscapes, and thrilling activities. Journey from the lush Chiriquí Highlands to the tropical splendor of Bocas del Toro, experience the historic charm of Panama City, and navigate the iconic Panama Canal. Enjoy snorkeling, hiking, and coffee tasting while encountering diverse wildlife and pristine beaches. This tour promises unique experiences, blending adventure and relaxation for an unforgettable trip across Panama’s top highlights.

Adventure

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Bastimentos, Boquet

Panama City, Bastimentos, Boquete, Bocas Del Toro

Duration6 days

From

USD 1,409

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San Blas Yanis Island Budget Experience 3D/2N - October 2025

No booking fees

Best price guaranteed

Discover the ultimate tropical escape with a budget-friendly adventure to San Blas Yanis Island. Immerse yourself in pristine beaches, crystal-clear waters, and authentic Kuna culture. This unforgettable experience includes island-hopping tours, snorkeling vibrant coral reefs, and savoring delicious local cuisine. Perfect for nature enthusiasts and cultural explorers, this San Blas adventure promises breathtaking scenery and unique cultural insights. Enjoy an affordable yet enriching getaway that highlights the stunning beauty and vibrant traditions of the San Blas Islands.

Adventure

Tour Type

Small Group Tour

Accommodation

Ship Cabin

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration3 days

From

USD 350

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Welcome to Panama City 4D/3N - October 2025

No booking fees

Best price guaranteed

Uncover the mystique of Panama City over four captivating days, where vibrant cultures intertwine with the timeless remnants of Casco Viejo. Traverse the enchanting streets and immerse yourself in the living history, intriguing architecture, and bustling local life that define this dynamic region. Each day unveils a new chapter of exploration, inviting you into the heart of Panama's most storied locales.

Explorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City

Duration4 days

From

USD 302

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Discover the Unseen Panama 13D/12N - October 2025

No booking fees

Best price guaranteed

Discover the mesmerizing fusion of vibrant city life and tranquil coastal paradises in Panama. Journey through historical sites, breathtaking beaches, and rich biodiversity, while uncovering the diverse cultural tapestry of this captivating nation. From Panama City's urban allure to Bocas del Toro's eco-escapades, every day offers a unique adventure amidst stunning landscapes and vibrant culture.

Explorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Bocas Del Toro, Pla

Panama City, Bocas Del Toro, Playa Venao, Santa Catalina, Boquete

Duration13 days

From

USD 2,038

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All Panama Tours in October 2025

11 Trips in Panama during October 2025

Get a customized trip to Panama in October 2025

11 Trips in Panama during October 2025

Combine Panama in October with Nearby Countries for an Unforgettable Trip

San Blas Chichime Islands Experience 4D/3N - October 2025

Panama City Express 5D/4N - October 2025

San Blas Cayos Holandeses Adventure 3D/2N - October 2025

San Blas Authentic Guna Yala Experience 4D/3N - October 2025

Welcome to Panama City 3D/2N - October 2025

San Blas Chichime Islands Experience 3D/2N - October 2025

San Blas Yanis Island Budget Experience 4D/3N - October 2025

Panama North to South Adventure 6D/5N - October 2025

San Blas Yanis Island Budget Experience 3D/2N - October 2025

Welcome to Panama City 4D/3N - October 2025

Discover the Unseen Panama 13D/12N - October 2025

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All Panama Tours in October 2025

11 Trips in Panama during October 2025

Get a customized trip to Panama in October 2025

11 Trips in Panama during October 2025