10 Best Tours and Trips in Panama City in 2025/2026 - Compare Prices

The best Panama City trips and multiday tour packages, delivered by top local Panama City travel specialists. Compare prices and 20+ reviews.

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Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

Guide Types

Guided Tours
Self Guided Tours

Price

USD 207USD 7,783

Budget Tours
Luxury Tours

Physical Rating

relaxed
easy
moderate
challenging

Page 2 of 37 Trips in Panama City with 25 Reviews

Showing 1 - 10 of 12 results

8% OFF TODAY

Black Week Super Sales

Wonders of Central America - 22 days

No booking fees

Best price guaranteed

Discover the natural and cultural highlights of six Central American countries on this three-week tour which travels from Panama to Guatemala. Visit wildlife-rich national parks and remote islands, uncover ancient secrets in Mayan ruins and roam around colonial cities.

City sightseeing

Tour Type

Group Tour

Accommodation

Hotel

Age Range

18-80 yrs

Operated in

english

Destinations

Panama City, Antigua, Granada, L

Panama City, Antigua, Granada, Leon, La Union, Boquete, Cahuita National Park, Monteverde, Ometepe Island

8% OFF TODAY

Duration22 days

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Central And South American Adventure: From Costa Rica To Colombia

13% OFF TODAY

Black Week Super Sales

Central and South American Adventure: From Costa Rica to Colombia

No booking fees

Best price guaranteed

Phones charged and playlists queued — this 27-day journey is a full-on adventure through Central and South America that’s packed with wild nature, laid-back beach towns, and buzzing cities. Start in Costa Rica with the surfy chill of Puerto Viejo before heading into Panama’s hidden gems — think island time in Bocas del Toro, misty hikes in Boquete, and the crater village of Valle de Antón. Then go fully off-grid on the San Blas Islands, where Indigenous communities run the show and turquoise water meets white sand. After that, it’s Colombia time. Wander Cartagena’s colourful old town, trek through jungle trails to waterfalls in Minca, kick back in Santa Marta, and finish strong in Medellín with mountaintop views and a nightlife scene to match. From slow travel moments to fast-paced fun, this one’s got it all.

Explorer

Tour Type

Small Group Tour

Accommodation

Guest House, Hostel, Hotel, Hut

Age Range

18-39 yrs

Operated in

english

Destinations

San Jose, Medellin, Valle De Ant

San Jose, Medellin, Valle De Antón, Panama City, San Blas Islands, Cartagena, Puerto Viejo de Talamanca, Minca, Palomino, Tayrona National Park, Santa Marta, Bocas Del Toro, Boquete

13% OFF TODAY

Duration27 days

View Tour

Tour Types

Small group tours
Independent tours
Private tours
Group tours

Duration

3 days62 days

Day Tour
Multiday Tour

Upcoming Departures

Dec 06

10+ seats remaining

Jan 03

10+ seats remaining

Upcoming Departures

May 05

10+ seats remaining

Jun 02

10+ seats remaining

Start & End Location

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

Panama City Tours and Trips

Create a customized tour to Panama City and Panama

Page 2 of 37 Trips in Panama City with 25 Reviews

Wonders of Central America - 22 days

Central and South American Adventure: From Costa Rica to Colombia

Page 2 of 37 Trips in Panama City with 25 Reviews