10 Best Panama City Multiday Tours in December 2025

Get a customized trip to Panama City in December 2025

Plan a multi-country or regional adventure across Panama City in December 2025, with help from a local expert.

Olman RomeroTravel Expert in Costa Rica, Nicaragua & Panama
Yuliana ValverdeTravel Expert in Costa Rica, Nicaragua & Panama

Start planning your Trip

Recommended by

Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

San Blas Cayos Holandeses Adventure 3D/2N - December 2025

No booking fees

Best price guaranteed

Embark on a captivating San Blas adventure in the pristine Cayos Holandeses, a hidden gem in Panama. Enjoy snorkeling in crystal-clear waters, exploring remote islands, and immersing in the rich Kuna culture. Discover exotic marine life, serene beaches, and stunning sunsets that will leave you breathless. Ideal for eco-travelers and adventure seekers, this trip offers an unforgettable mix of relaxation and exploration. Book now and experience the ultimate island escape in the heart of Panama's Caribbean paradise!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration3 days

From

USD 583

USD 566

Saving

USD 17

View Tour

Halloween Super Sales

Wonders of Central America - 22 days - December 2025

No booking fees

Best price guaranteed

Discover the natural and cultural highlights of six Central American countries on this three-week tour which travels from Panama to Guatemala. Visit wildlife-rich national parks and remote islands, uncover ancient secrets in Mayan ruins and roam around colonial cities.

City sightseeing

Tour Type

Group Tour

Accommodation

Hotel

Age Range

18-80 yrs

Operated in

english

Destinations

Panama City, Antigua, Granada, L

Panama City, Antigua, Granada, Leon, Boquete, Cahuita National Park, Monteverde, Ometepe Island

Duration22 days

From

USD 5,935

USD 5,757

Saving

USD 178

View Tour

All Panama City Tours in December 2025

Page 2 of 16 Trips in Panama City during December 2025

Get a customized trip to Panama City in December 2025

Page 2 of 16 Trips in Panama City during December 2025

San Blas Cayos Holandeses Adventure 3D/2N - December 2025

Wonders of Central America - 22 days - December 2025

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Panama City Tours in December 2025

Page 2 of 16 Trips in Panama City during December 2025

Get a customized trip to Panama City in December 2025

Page 2 of 16 Trips in Panama City during December 2025

San Blas Cayos Holandeses Adventure 3D/2N - December 2025

Wonders of Central America - 22 days - December 2025