10 Best Panama City Multiday Tours in December 2025

Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

Costa Rica & Panama Discovery - December 2025

19% OFF TODAY

Halloween Super Sales

Costa Rica & Panama Discovery - December 2025

(1 review )

No booking fees

Best price guaranteed

Get under the surface of Costa Rica and Panama with this 12-day Caribbean adventure. From San Jose to Panama City, you’ll get introduced to some of the most beautiful spots in two Central American countries, with a perfect balance of included activities and free time for your own explorations. You’ll visit the Ngabe-Bugle community on Isla Popa, learn how to make a traditional Caribbean meal, look out for wildlife on a jungle walk, visit a lock along the Panama Canal and soak in the local hotspots in areas seldom travelled. You can't go wrong with your local leader to steer you in the right direction (to the best bars and surf breaks), plus a small group of adventurers to enjoy them with.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

15-99 yrs

Operated in

english

Destinations

Panama City, San Jose, Puerto Vi

Panama City, San Jose, Puerto Viejo de Talamanca, Chitre, Isla Colon, Bocas Del Toro, Boquete

19% OFF TODAY

Duration12 days

From

USD 2,110

USD 1,704

Saving

USD 406

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5% OFF TODAY

San Blas Yanis Island Budget Experience 4D/3N - December 2025

No booking fees

Best price guaranteed

Embark on a captivating journey from the bustling streets of Panama City to the secluded serenity of the San Blas Islands. Traverse lush jungles, immerse yourself in pristine waters, and explore idyllic islands. This tropical adventure promises tranquillity and natural beauty, from coral reefs to vibrant sunsets.

Adventure

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration4 days

From

USD 421

USD 400

Saving

USD 21

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15% OFF TODAY

Halloween Super Sales

Best of Central America - December 2025

No booking fees

Best price guaranteed

Explore incredible worlds above and below the water through some of Central America's best on this 45-day adventure. Amble down the Yucatan Peninsula to the island paradise of Caye Caulker, then cut inland to the lush jungle around Tikal, cruise to the wide river Rio Dulce and end up among the clouds in Panajachel and Antigua. Continue to the relaxing beach vibes of the Pacific Coast of El Salvador, spot colourful birds perched on the historic facades of Suchitoto and explore the historic cities of Leon and Granada in Nicaragua. Stand in the shadow of mighty Arenal Volcano and spot sloths among the canopy of Monteverde, then admire the towns and steamy jungles of Costa Rice and Panama, stopping off at the stunning islands of Bocas del Toro. With plenty of moments to meet the locals and try the region’s varied cuisines, you can’t go wrong on this carefree Central American journey.

WildlifeCity sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel, Hut, Lodge

Age Range

15-99 yrs

Operated in

english

Destinations

Panama City, Playa Del Carmen, R

Panama City, Playa Del Carmen, Rio Dulce, Antigua, Quetzaltenango, Panajachel, Tulum, Copan, Suchitoto, La Libertad, Leon, Granada, Monteverde, La Fortuna, San Jose, Sarapiqui, Puerto Viejo de Talamanca, Bocas Del Toro, Caye Caulker, Boquete, Chitre, San Ignacio, Flores

15% OFF TODAY

Duration45 days

From

USD 7,390

USD 6,318

Saving

USD 1,072

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5% OFF TODAY

Halloween Super Sales

Amazing Central America - December 2025

No booking fees

Best price guaranteed

Get ready for a 27-day adventure through Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica and Panama. From oceans teeming with marine life to tropical forests alive with jungle melodies, this pocket of Central America is truly a natural paradise. You’ll explore the intricately carved structures at Copan, the cloud forests of Monteverde and spend three nights in the island paradise of Bocas del Toro. Sample varied cuisines along the way during cooking lessons with locals, giving you a real insight into the heart and soul of Central America.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel, Hut

Age Range

15-99 yrs

Operated in

english

Destinations

Panama City, San Jose, Antigua

Panama City, San Jose, Antigua, Monteverde Cloud Forest Biological Preserve, Puerto Viejo de Talamanca, Cahuita National Park, Granada, Monteverde, La Fortuna, Sarapiqui, Copan, Bocas Del Toro, Boquete, Chitre, Suchitoto, El Cuco, Leon

5% OFF TODAY

Duration27 days

From

USD 4,030

USD 3,829

Saving

USD 202

View Tour

5% OFF TODAY

San Blas Chichime Islands Experience 3D/2N - December 2025

No booking fees

Best price guaranteed

Embark on an unforgettable island adventure with pristine beaches, crystal-clear waters, and vibrant indigenous culture. Discover the natural beauty of the San Blas Chichime Islands, where you can snorkel among colorful coral reefs, savor fresh seafood, and immerse yourself in the laid-back Kuna lifestyle. Perfect for nature lovers and culture enthusiasts, this tropical getaway promises breathtaking sunsets, starry nights, and endless relaxation. Book your San Blas Island escape today for an authentic Caribbean experience.

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration3 days

From

USD 458

USD 435

Saving

USD 23

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5% OFF TODAY

Panama North to South Adventure 6D/5N - December 2025

No booking fees

Best price guaranteed

Discover the ultimate Panama adventure tour, immersing yourself in vibrant cultures, stunning landscapes, and thrilling activities. Journey from the lush Chiriquí Highlands to the tropical splendor of Bocas del Toro, experience the historic charm of Panama City, and navigate the iconic Panama Canal. Enjoy snorkeling, hiking, and coffee tasting while encountering diverse wildlife and pristine beaches. This tour promises unique experiences, blending adventure and relaxation for an unforgettable trip across Panama’s top highlights.

Adventure

Tour Type

Small Group Tour

Accommodation

Hotel, Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Bastimentos, Boquet

Panama City, Bastimentos, Boquete, Bocas Del Toro

5% OFF TODAY

Duration6 days

From

USD 1,409

USD 1,339

Saving

USD 70

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5% OFF TODAY

Panama City Express 5D/4N - December 2025

No booking fees

Best price guaranteed

Experience the vibrant culture and stunning sights of Panama City in this unforgettable adventure. Discover the historic charm of Casco Viejo, marvel at the engineering wonder of the Panama Canal, and explore the lush biodiversity of the Rainforest Discovery Center. This immersive journey offers a perfect blend of modern city life and natural beauty, providing travelers with unique experiences and unforgettable memories. Join us for a diverse and exciting exploration of one of Central America's most captivating destinations.

AdventureWildlifeBicycle tours

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City

5% OFF TODAY

Duration5 days

From

USD 1,162

USD 1,104

Saving

USD 58

View Tour

5% OFF TODAY

San Blas Yanis Island Budget Experience 3D/2N - December 2025

No booking fees

Best price guaranteed

Discover the ultimate tropical escape with a budget-friendly adventure to San Blas Yanis Island. Immerse yourself in pristine beaches, crystal-clear waters, and authentic Kuna culture. This unforgettable experience includes island-hopping tours, snorkeling vibrant coral reefs, and savoring delicious local cuisine. Perfect for nature enthusiasts and cultural explorers, this San Blas adventure promises breathtaking scenery and unique cultural insights. Enjoy an affordable yet enriching getaway that highlights the stunning beauty and vibrant traditions of the San Blas Islands.

Adventure

Tour Type

Small Group Tour

Accommodation

Ship Cabin

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration3 days

From

USD 350

USD 333

Saving

USD 18

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5% OFF TODAY

San Blas Authentic Guna Yala Experience 4D/3N - December 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure to the San Blas Islands, immersing yourself in the vibrant Guna Yala culture. Revel in pristine beaches, crystal-clear waters, and charming island stays. Highlights include traditional Guna crafts, snorkeling amid colorful reefs, and savoring fresh, local cuisine. Perfect for culture enthusiasts and nature lovers alike, this tour promises an authentic, off-the-beaten-path experience. Unwind in paradise and discover the untouched beauty of Panama's hidden gem. Book your ultimate island getaway now!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration4 days

From

USD 432

USD 410

Saving

USD 22

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Ultimate Central America - December 2025

14% OFF TODAY

Halloween Super Sales

Ultimate Central America - December 2025

No booking fees

Best price guaranteed

Embark on an in-depth, 59-day Central American adventure from Mexico’s capital to the home of the Panama Canal. Pass through Mexico, Belize, Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica and Panama on a small-group journey through remote villages, historic cities, ancient Maya and Aztec ruins, verdant cloud forests and pure Caribbean beaches. Get acquainted with the local cultures, spectacular landscapes and fascinating histories of Central America as you explore the wealth of tradition, spot the range of unusual wildlife, dive into unique underwater worlds and spend time travelling with like-minded people. Did you hear that? Central America is calling – you better Belize it.

City sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel, Hut, Lodge

Age Range

15-99 yrs

Operated in

english

Destinations

Mexico City, Panama City, Palenq

Mexico City, Panama City, Palenque, Merida, Playa Del Carmen, Chetumal, Caye Caulker, San Ignacio, Flores, Rio Dulce, Antigua, Quetzaltenango, Puebla, Panajachel, Copan, Suchitoto, La Libertad, Leon, Granada, Monteverde, La Fortuna, San Jose, Sarapiqui, Oaxaca, Puerto Viejo de Talamanca, Bocas Del Toro, Boquete, Chitre, San Cristobal De Las Casas

14% OFF TODAY

Duration59 days

From

USD 10,390

USD 8,883

Saving

USD 1,507

View Tour

5% OFF TODAY

Discover the Unseen Panama 13D/12N - December 2025

No booking fees

Best price guaranteed

Discover the mesmerizing fusion of vibrant city life and tranquil coastal paradises in Panama. Journey through historical sites, breathtaking beaches, and rich biodiversity, while uncovering the diverse cultural tapestry of this captivating nation. From Panama City's urban allure to Bocas del Toro's eco-escapades, every day offers a unique adventure amidst stunning landscapes and vibrant culture.

Explorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Bocas Del Toro, Pla

Panama City, Bocas Del Toro, Playa Venao, Santa Catalina, Boquete

5% OFF TODAY

Duration13 days

From

USD 2,038

USD 1,936

Saving

USD 102

View Tour

5% OFF TODAY

San Blas Cayos Holandeses Adventure 3D/2N - December 2025

No booking fees

Best price guaranteed

Embark on a captivating San Blas adventure in the pristine Cayos Holandeses, a hidden gem in Panama. Enjoy snorkeling in crystal-clear waters, exploring remote islands, and immersing in the rich Kuna culture. Discover exotic marine life, serene beaches, and stunning sunsets that will leave you breathless. Ideal for eco-travelers and adventure seekers, this trip offers an unforgettable mix of relaxation and exploration. Book now and experience the ultimate island escape in the heart of Panama's Caribbean paradise!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration3 days

From

USD 583

USD 554

Saving

USD 29

View Tour

5% OFF TODAY

Wonders of Central America - 22 days - December 2025

No booking fees

Best price guaranteed

Discover the natural and cultural highlights of six Central American countries on this three-week tour which travels from Panama to Guatemala. Visit wildlife-rich national parks and remote islands, uncover ancient secrets in Mayan ruins and roam around colonial cities.

City sightseeing

Tour Type

Group Tour

Accommodation

Hotel

Age Range

18-80 yrs

Operated in

english

Destinations

Panama City, Antigua, Granada, L

Panama City, Antigua, Granada, Leon, Boquete, Cahuita National Park, Monteverde, Ometepe Island

5% OFF TODAY

Duration22 days

From

USD 5,935

USD 5,638

Saving

USD 297

View Tour

5% OFF TODAY

San Blas Chichime Islands Experience 4D/3N - December 2025

No booking fees

Best price guaranteed

Escape to a tropical paradise with an unforgettable adventure in the San Blas Chichime Islands. Revel in pristine beaches, crystal-clear waters, and vibrant marine life. Snorkel around coral reefs, interact with the indigenous Guna Yala community, and savor mouthwatering seafood. Enjoy the rustic charm of island cabins amidst swaying palms. Ideal for travelers seeking relaxation and exploration, this experience offers the perfect blend of cultural immersion and natural beauty. Discover why the San Blas Islands are a top bucket-list destination.

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration4 days

From

USD 575

USD 546

Saving

USD 29

View Tour

All Panama City Tours in December 2025

16 Trips in Panama City during December 2025

Get a customized trip to Panama City in December 2025

16 Trips in Panama City during December 2025

Costa Rica & Panama Discovery - December 2025

San Blas Yanis Island Budget Experience 4D/3N - December 2025

Best of Central America - December 2025

Amazing Central America - December 2025

San Blas Chichime Islands Experience 3D/2N - December 2025

Panama North to South Adventure 6D/5N - December 2025

Panama City Express 5D/4N - December 2025

San Blas Yanis Island Budget Experience 3D/2N - December 2025

San Blas Authentic Guna Yala Experience 4D/3N - December 2025

Ultimate Central America - December 2025

Discover the Unseen Panama 13D/12N - December 2025

San Blas Cayos Holandeses Adventure 3D/2N - December 2025

Wonders of Central America - 22 days - December 2025

San Blas Chichime Islands Experience 4D/3N - December 2025

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Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Panama City Tours in December 2025

16 Trips in Panama City during December 2025

Get a customized trip to Panama City in December 2025

16 Trips in Panama City during December 2025