10 Best Panama City Multiday Tours in December 2025

Get a customized trip to Panama City in December 2025

Plan a multi-country or regional adventure across Panama City in December 2025, with help from a local expert.

Olman RomeroTravel Expert in Costa Rica, Nicaragua & Panama
Yuliana ValverdeTravel Expert in Costa Rica, Nicaragua & Panama

Start planning your Trip

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5% OFF TODAY

San Blas Chichime Islands Experience 3D/2N - December 2025

No booking fees

Best price guaranteed

Embark on an unforgettable island adventure with pristine beaches, crystal-clear waters, and vibrant indigenous culture. Discover the natural beauty of the San Blas Chichime Islands, where you can snorkel among colorful coral reefs, savor fresh seafood, and immerse yourself in the laid-back Kuna lifestyle. Perfect for nature lovers and culture enthusiasts, this tropical getaway promises breathtaking sunsets, starry nights, and endless relaxation. Book your San Blas Island escape today for an authentic Caribbean experience.

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

5% OFF TODAY

Duration3 days

From

USD 458

USD 435

Saving

USD 23

View Tour

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Panama City to Mexico Maya Express Pass - December 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure with Bamba's Panama City to Mexico Maya Express Pass! Traverse vibrant Central America, exploring lush rainforests, pristine beaches, and ancient Mayan ruins. Indulge in rich cultural experiences and exhilarating activities like zip-lining, snorkeling, and more. Perfect for thrill-seekers and culture enthusiasts, this tour promises breathtaking scenery and unforgettable memories. Discover hidden gems, savor local cuisines, and immerse yourself in diverse traditions on this captivating journey from Panama to Mexico.

Active and outdoor

Tour Type

Group Tour

Accommodation

Hostel, Home-stay, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Cancún, San Blas Is

Panama City, Cancún, San Blas Islands, San Jose, Monteverde Cloud Forest Biological Preserve, San Juan Del Sur, Granada, Leon, El Tunco, Antigua, Panajachel, San Jorge La Laguna, Lanquin, Flores, Belize City, Caye Caulker, Chetumal, Tulum, Playa Del Carmen, Bocas Del Toro, Puerto Viejo de Talamanca, Tortuguero National Park

5% OFF TODAY

Duration40 days

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Mexico City to Panama City Travel Pass - December 2025

No booking fees

Best price guaranteed

Discover the ultimate adventure from Mexico City to Panama City with this travel pass, offering a thrilling journey through Central America's cultural and natural wonders. Explore ancient Mayan ruins, lush rainforests, stunning beaches, and vibrant cities. Experience authentic local cuisine, breathtaking landscapes, and diverse wildlife. This adventure guarantees an unforgettable blend of history, nature, and adventure-packed activities, ideal for those seeking to immerse themselves in the rich and varied tapestry of Central America.

Overland Journeys

Tour Type

Group Tour

Accommodation

Home-stay, Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Mexico City, Panama City, Palenq

Mexico City, Panama City, Palenque, Merida, Playa Del Carmen, Tulum, Bacalar, Chetumal, Caye Caulker, Oaxaca, Belize City, Flores, Rio Dulce, Lanquin, Panajachel, San Jorge La Laguna, Antigua, Copán Ruinas, El Tunco, Leon, Granada, San Jorge, San Juan Del Sur, Monteverde Cloud Forest Biological Preserve, Manuel Antonio National Park, San Jose, Puerto Escondido, Puerto Viejo de Talamanca, Bocas Del Toro, San Blas Islands, Pochutla, San Cristobal De Las Casas

5% OFF TODAY

Duration57 days

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Panama City to Antigua Travel Pass - December 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure from Panama City to Antigua with Bamba Travel! Explore vibrant Panama City's historic sites, traverse lush jungles, and marvel at volcanic landscapes. Discover the charm of colonial towns, experience rich cultures, and enjoy thrilling activities like hiking, zip-lining, and local market tours. This immersive journey promises diverse natural beauty and unique experiences, ensuring every traveler captures the essence of Central America's allure. Join us for an adventure-packed exploration and create memories to last a lifetime!

Active and outdoorAdventure

Tour Type

Group Tour

Accommodation

Hostel, Home-stay, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Antigua, San Blas I

Panama City, Antigua, San Blas Islands, San Jose, Manuel Antonio National Park, Monteverde Cloud Forest Biological Preserve, San Juan Del Sur, San Jorge, Isla Ometepe, Granada, Leon, San Salvador, Copán Ruinas, Panajachel, San Jorge La Laguna, Lanquin, Bocas Del Toro, Puerto Viejo de Talamanca, Tortuguero National Park

5% OFF TODAY

Duration36 days

5% OFF TODAY

Cancun to Panama City Travel Pass - December 2025

No booking fees

Best price guaranteed

Embark on an unforgettable Central American adventure, exploring pristine beaches, vibrant cities, and lush jungles. This travel pass takes you from Cancun to Panama City, offering immersive experiences like snorkeling in Belize’s Blue Hole, discovering Mayan ruins in Guatemala, and hiking Costa Rica’s volcanoes. Enjoy local cultures, authentic cuisines, and breathtaking landscapes. Perfect for thrill-seekers and culture enthusiasts, this journey provides incredible opportunities to make lasting memories while venturing through this diverse and captivating region.

Active and outdoor

Tour Type

Group Tour

Accommodation

Hostel, Home-stay, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, Cancún, Belize City

Panama City, Cancún, Belize City, Flores, Rio Dulce, Lanquin, Panajachel, San Jorge La Laguna, Playa Del Carmen, Antigua, Copán Ruinas, El Tunco, Leon, Granada, San Jorge, San Juan Del Sur, Monteverde Cloud Forest Biological Preserve, Manuel Antonio National Park, San Jose, Tulum, Tortuguero, Puerto Viejo De Sarapiqui, Bocas Del Toro, San Blas Islands, Bacalar, Chetumal, Caye Caulker

5% OFF TODAY

Duration48 days

All Panama City Tours in December 2025

5 Trips in Panama City during December 2025

Get a customized trip to Panama City in December 2025

5 Trips in Panama City during December 2025

San Blas Chichime Islands Experience 3D/2N - December 2025

Panama City to Mexico Maya Express Pass - December 2025

Mexico City to Panama City Travel Pass - December 2025

Panama City to Antigua Travel Pass - December 2025

Cancun to Panama City Travel Pass - December 2025

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Panama City Tours in December 2025

5 Trips in Panama City during December 2025

Get a customized trip to Panama City in December 2025

5 Trips in Panama City during December 2025

San Blas Chichime Islands Experience 3D/2N - December 2025

Panama City to Mexico Maya Express Pass - December 2025

Mexico City to Panama City Travel Pass - December 2025

Panama City to Antigua Travel Pass - December 2025

Cancun to Panama City Travel Pass - December 2025