10 Best Panama City Multiday Tours in April 2026

Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

Get a customized trip to Panama City in April 2026

Plan a multi-country or regional adventure across Panama City in April 2026, with help from a local expert.

Olman RomeroTravel Expert in Costa Rica, Nicaragua & Panama
Yuliana ValverdeTravel Expert in Costa Rica, Nicaragua & Panama

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Recommended by

San Blas Yanis Island Budget Experience 4D/3N - April 2026

No booking fees

Best price guaranteed

Embark on a captivating journey from the bustling streets of Panama City to the secluded serenity of the San Blas Islands. Traverse lush jungles, immerse yourself in pristine waters, and explore idyllic islands. This tropical adventure promises tranquillity and natural beauty, from coral reefs to vibrant sunsets.

Adventure

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 421

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San Blas Chichime Islands Experience 3D/2N - April 2026

No booking fees

Best price guaranteed

Embark on an unforgettable island adventure with pristine beaches, crystal-clear waters, and vibrant indigenous culture. Discover the natural beauty of the San Blas Chichime Islands, where you can snorkel among colorful coral reefs, savor fresh seafood, and immerse yourself in the laid-back Kuna lifestyle. Perfect for nature lovers and culture enthusiasts, this tropical getaway promises breathtaking sunsets, starry nights, and endless relaxation. Book your San Blas Island escape today for an authentic Caribbean experience.

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration3 days

From

USD 458

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Panama City Express 5D/4N - April 2026

No booking fees

Best price guaranteed

Experience the vibrant culture and stunning sights of Panama City in this unforgettable adventure. Discover the historic charm of Casco Viejo, marvel at the engineering wonder of the Panama Canal, and explore the lush biodiversity of the Rainforest Discovery Center. This immersive journey offers a perfect blend of modern city life and natural beauty, providing travelers with unique experiences and unforgettable memories. Join us for a diverse and exciting exploration of one of Central America's most captivating destinations.

AdventureWildlifeBicycle tours

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City

Duration5 days

From

USD 1,162

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San Blas Authentic Guna Yala Experience 4D/3N - April 2026

No booking fees

Best price guaranteed

Embark on an unforgettable adventure to the San Blas Islands, immersing yourself in the vibrant Guna Yala culture. Revel in pristine beaches, crystal-clear waters, and charming island stays. Highlights include traditional Guna crafts, snorkeling amid colorful reefs, and savoring fresh, local cuisine. Perfect for culture enthusiasts and nature lovers alike, this tour promises an authentic, off-the-beaten-path experience. Unwind in paradise and discover the untouched beauty of Panama's hidden gem. Book your ultimate island getaway now!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 432

View Tour

All Panama City Tours in April 2026

4 Trips in Panama City during April 2026

Get a customized trip to Panama City in April 2026

4 Trips in Panama City during April 2026

San Blas Yanis Island Budget Experience 4D/3N - April 2026

San Blas Chichime Islands Experience 3D/2N - April 2026

Panama City Express 5D/4N - April 2026

San Blas Authentic Guna Yala Experience 4D/3N - April 2026

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Panama City Tours in April 2026

4 Trips in Panama City during April 2026

Get a customized trip to Panama City in April 2026

4 Trips in Panama City during April 2026

San Blas Yanis Island Budget Experience 4D/3N - April 2026

San Blas Chichime Islands Experience 3D/2N - April 2026

Panama City Express 5D/4N - April 2026

San Blas Authentic Guna Yala Experience 4D/3N - April 2026