10 Best Panama City Multiday Tours in April 2026

Best of Panama - April 2026

(2 reviews )

Trip customizable

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Nice Trip and amazing arrangements. Will love to travel again!

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

8-99 yrs

Operated in

english

Destinations

Panama City, Boquete, San Blas I

Panama City, Boquete, San Blas Islands, Isla Colon, Bocas Del Toro

Duration12 days

From

USD 3,517

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Costa Rica & Panama Discovery - April 2026

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Costa Rica & Panama Discovery - April 2026

(1 review )

No booking fees

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Get under the surface of Costa Rica and Panama with this 12-day Caribbean adventure. From San Jose to Panama City, you’ll get introduced to some of the most beautiful spots in two Central American countries, with a perfect balance of included activities and free time for your own explorations. You’ll visit the Ngabe-Bugle community on Isla Popa, learn how to make a traditional Caribbean meal, look out for wildlife on a jungle walk, visit a lock along the Panama Canal and soak in the local hotspots in areas seldom travelled. You can't go wrong with your local leader to steer you in the right direction (to the best bars and surf breaks), plus a small group of adventurers to enjoy them with.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

15-99 yrs

Operated in

english

Destinations

Panama City, San Jose, Puerto Vi

Panama City, San Jose, Puerto Viejo de Talamanca, Chitre, Isla Colon, Bocas Del Toro, Boquete

18% OFF TODAY

Duration12 days

From

USD 2,110

USD 1,740

Saving

USD 370

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San Blas Yanis Island Budget Experience 4D/3N - April 2026

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Best price guaranteed

Embark on a captivating journey from the bustling streets of Panama City to the secluded serenity of the San Blas Islands. Traverse lush jungles, immerse yourself in pristine waters, and explore idyllic islands. This tropical adventure promises tranquillity and natural beauty, from coral reefs to vibrant sunsets.

Adventure

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 421

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18% OFF TODAY

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Best of Central America - April 2026

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Explore incredible worlds above and below the water through some of Central America's best on this 45-day adventure. Amble down the Yucatan Peninsula to the island paradise of Caye Caulker, then cut inland to the lush jungle around Tikal, cruise to the wide river Rio Dulce and end up among the clouds in Panajachel and Antigua. Continue to the relaxing beach vibes of the Pacific Coast of El Salvador, spot colourful birds perched on the historic facades of Suchitoto and explore the historic cities of Leon and Granada in Nicaragua. Stand in the shadow of mighty Arenal Volcano and spot sloths among the canopy of Monteverde, then admire the towns and steamy jungles of Costa Rice and Panama, stopping off at the stunning islands of Bocas del Toro. With plenty of moments to meet the locals and try the region’s varied cuisines, you can’t go wrong on this carefree Central American journey.

WildlifeCity sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel, Hut, Lodge

Age Range

15-99 yrs

Operated in

english

Destinations

Panama City, Playa Del Carmen, R

Panama City, Playa Del Carmen, Rio Dulce, Antigua, Quetzaltenango, Panajachel, Tulum, Copan, Suchitoto, La Libertad, Leon, Granada, Monteverde, La Fortuna, San Jose, Sarapiqui, Puerto Viejo de Talamanca, Bocas Del Toro, Caye Caulker, Boquete, Chitre, San Ignacio, Flores

18% OFF TODAY

Duration45 days

From

USD 7,390

USD 6,093

Saving

USD 1,297

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Amazing Central America - April 2026

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Best price guaranteed

Get ready for a 27-day adventure through Guatemala, Honduras, El Salvador, Nicaragua, Costa Rica and Panama. From oceans teeming with marine life to tropical forests alive with jungle melodies, this pocket of Central America is truly a natural paradise. You’ll explore the intricately carved structures at Copan, the cloud forests of Monteverde and spend three nights in the island paradise of Bocas del Toro. Sample varied cuisines along the way during cooking lessons with locals, giving you a real insight into the heart and soul of Central America.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel, Hut

Age Range

15-99 yrs

Operated in

english

Destinations

Panama City, San Jose, Antigua

Panama City, San Jose, Antigua, Monteverde Cloud Forest Biological Preserve, Puerto Viejo de Talamanca, Cahuita National Park, Granada, Monteverde, La Fortuna, Sarapiqui, Copan, Bocas Del Toro, Boquete, Chitre, Suchitoto, El Cuco, Leon

Duration27 days

From

USD 4,030

USD 3,909

Saving

USD 121

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San Blas Chichime Islands Experience 3D/2N - April 2026

No booking fees

Best price guaranteed

Embark on an unforgettable island adventure with pristine beaches, crystal-clear waters, and vibrant indigenous culture. Discover the natural beauty of the San Blas Chichime Islands, where you can snorkel among colorful coral reefs, savor fresh seafood, and immerse yourself in the laid-back Kuna lifestyle. Perfect for nature lovers and culture enthusiasts, this tropical getaway promises breathtaking sunsets, starry nights, and endless relaxation. Book your San Blas Island escape today for an authentic Caribbean experience.

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration3 days

From

USD 458

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Glimpse of Panama - April 2026

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Visit Panama City and discover its history and charm along with the famous Panama Canal. You will learn about the events in history that lead to the eventual movement of the capital city to its present location. You will experience the facets of the Panama Canal combining the history of this amazing feat of human engineering with the biodiversity. Explore the Soberania National Park where you will enjoy a hike and you will have the opportunity to observe birds, mammals in the tropical rainforest before returning to Panama City, where your tour ends.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

8-99 yrs

Operated in

english

Destinations

Panama City, Soberanía National Park

Duration6 days

From

USD 1,784

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Panama City Express 5D/4N - April 2026

No booking fees

Best price guaranteed

Experience the vibrant culture and stunning sights of Panama City in this unforgettable adventure. Discover the historic charm of Casco Viejo, marvel at the engineering wonder of the Panama Canal, and explore the lush biodiversity of the Rainforest Discovery Center. This immersive journey offers a perfect blend of modern city life and natural beauty, providing travelers with unique experiences and unforgettable memories. Join us for a diverse and exciting exploration of one of Central America's most captivating destinations.

AdventureWildlifeBicycle tours

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City

Duration5 days

From

USD 1,162

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San Blas Authentic Guna Yala Experience 4D/3N - April 2026

No booking fees

Best price guaranteed

Embark on an unforgettable adventure to the San Blas Islands, immersing yourself in the vibrant Guna Yala culture. Revel in pristine beaches, crystal-clear waters, and charming island stays. Highlights include traditional Guna crafts, snorkeling amid colorful reefs, and savoring fresh, local cuisine. Perfect for culture enthusiasts and nature lovers alike, this tour promises an authentic, off-the-beaten-path experience. Unwind in paradise and discover the untouched beauty of Panama's hidden gem. Book your ultimate island getaway now!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration4 days

From

USD 432

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18% OFF TODAY

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Ultimate Central America - April 2026

No booking fees

Best price guaranteed

Embark on an in-depth, 59-day Central American adventure from Mexico’s capital to the home of the Panama Canal. Pass through Mexico, Belize, Guatemala, El Salvador, Honduras, Nicaragua, Costa Rica and Panama on a small-group journey through remote villages, historic cities, ancient Maya and Aztec ruins, verdant cloud forests and pure Caribbean beaches. Get acquainted with the local cultures, spectacular landscapes and fascinating histories of Central America as you explore the wealth of tradition, spot the range of unusual wildlife, dive into unique underwater worlds and spend time travelling with like-minded people. Did you hear that? Central America is calling – you better Belize it.

City sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel, Hut, Lodge

Age Range

15-99 yrs

Operated in

english

Destinations

Mexico City, Panama City, Palenq

Mexico City, Panama City, Palenque, Merida, Playa Del Carmen, Chetumal, Caye Caulker, San Ignacio, Flores, Rio Dulce, Antigua, Quetzaltenango, Puebla, Panajachel, Copan, Suchitoto, La Libertad, Leon, Granada, Monteverde, La Fortuna, San Jose, Sarapiqui, Oaxaca, Puerto Viejo de Talamanca, Bocas Del Toro, Boquete, Chitre, San Cristobal De Las Casas

18% OFF TODAY

Duration59 days

From

USD 10,390

USD 8,567

Saving

USD 1,823

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Treasures of Costa Rica and Panama - April 2026

(1 review )

Trip customizable

Best price guaranteed

We loved our trip to Costa Rica/Panama and it was a perfect mix of tours and time on our own. The guides were all great and the hotels (including breakfast) all good -- one less so but not bad... Highly recommend this trip!

National parksWildlife

Tour Type

Small Group Tour

Accommodation

Hotel, Villa

Age Range

8-99 yrs

Operated in

english

Destinations

Panama City, San Jose, Panama Ca

Panama City, San Jose, Panama Canal, Soberanía National Park, Arenal, Monteverde, Manuel Antonio

Duration13 days

From

USD 2,939

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Panama: Craters, Coasts & Highland Mountains - April 2026

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Best price guaranteed

Eighteen days of next-level beaches, wild landscapes, and full-on freedom — this is Panama like you’ve never seen it. Start in Costa Rica and cruise into the often-overlooked magic of Panama, where every stop hits different. Catch the surfy vibes in Puerto Viejo, snorkel your heart out in Bocas del Toro, and hike cloud forest trails in lush Boquete. Sleep inside a volcanic crater in the town of Valle de Antón, dance the night away in Panama City, and unplug completely with three off-the-grid nights on the jaw-dropping San Blas Islands. Between waterfalls, reefs, Indigenous culture, and epic new friendships, this trip brings the kind of stories you’ll be telling for years.

Explorer

Tour Type

Small Group Tour

Accommodation

Guest House, Hostel, Hotel, Hut

Age Range

18-39 yrs

Operated in

english

Destinations

Panama City, San Jose, Valle De

Panama City, San Jose, Valle De Antón, San Blas Islands, Puerto Viejo de Talamanca, Bocas Del Toro, Boquete

Duration18 days

From

USD 2,049

USD 1,988

Saving

USD 61

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Costa Rica to Panama: Surf, Treks & Starry Skies - April 2026

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Best price guaranteed

Ready to bounce from beach to jungle to crater town? This 13-day trip kicks off in Costa Rica and cruises into the wild beauty of Panama, where laid-back vibes meet epic adventure. Chill out on the Caribbean coast in Puerto Viejo, snorkel through starfish-studded waters in Bocas del Toro, and hike cloud forest trails to hidden waterfalls in Boquete. You’ll get up close with local culture, learn how chocolate is made from the source, and hang out in Valle de Antón — an actual town inside a volcanic crater. Wrap it up with a night out in Panama City, and you’ve got a Central American escape that’s anything but basic.

Explorer

Tour Type

Small Group Tour

Accommodation

Guest House, Hostel, Hotel

Age Range

18-39 yrs

Operated in

english

Destinations

Panama City, San Jose, Valle De

Panama City, San Jose, Valle De Antón, Puerto Viejo de Talamanca, Bocas Del Toro, Boquete

Duration13 days

From

USD 1,199

USD 1,163

Saving

USD 36

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Panama: Sandy Beaches & San Blas Sunsets - April 2026

No booking fees

Best price guaranteed

Looking to unplug and drop off the grid in total island style? This 6-day adventure takes you from the buzz of Panama City to the untouched paradise of the San Blas Islands — and trust us, it’s next-level. Start by soaking in the city’s mix of modern energy and historic charm, before setting sail for the Caribbean. Picture crystal-clear water, palm trees swaying over white sand, and zero Wi-Fi to distract you. The San Blas Islands are run by the Indigenous Guna people, giving you the chance to connect with local culture and traditions while living that beachside barefoot dream. No filters needed — this is as real as paradise gets.

Explorer

Tour Type

Small Group Tour

Accommodation

Hotel, Hut

Age Range

18-39 yrs

Operated in

english

Destinations

Panama City, San Blas Islands

Duration6 days

From

USD 899

USD 872

Saving

USD 27

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All Panama City Tours in April 2026

17 Trips in Panama City during April 2026

Get a customized trip to Panama City in April 2026

Best of Panama - April 2026

Costa Rica & Panama Discovery - April 2026

San Blas Yanis Island Budget Experience 4D/3N - April 2026

Best of Central America - April 2026

Amazing Central America - April 2026

San Blas Chichime Islands Experience 3D/2N - April 2026

Glimpse of Panama - April 2026

Panama City Express 5D/4N - April 2026

San Blas Authentic Guna Yala Experience 4D/3N - April 2026

Ultimate Central America - April 2026

Treasures of Costa Rica and Panama - April 2026

Panama: Craters, Coasts & Highland Mountains - April 2026

Costa Rica to Panama: Surf, Treks & Starry Skies - April 2026

Panama: Sandy Beaches & San Blas Sunsets - April 2026

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South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Panama City Tours in April 2026

17 Trips in Panama City during April 2026

Get a customized trip to Panama City in April 2026