10 Best South America Multiday Tours in October 2025

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Cusco Day Tour: Humantay Lagoon Hike (full day) - October 2025

No booking fees

Best price guaranteed

This full-day excursion takes you trekking along one of the most spectacular stretches of the Salkantay Trail to the turquoise glacial lagoon of Humantay. An active escape from the city, this day tour is a perfect way to soak in the views of the Andes and to breathe the clean mountain air.

Trekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

12-100 yrs

Operated in

english

Destinations

Cusco

Duration1 day

From

USD 50

USD 49

Saving

USD 2

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Lima Day Tour: Highlights and Insiders Tour (full day) - October 2025

No booking fees

Best price guaranteed

Delve into Lima's culture and culinary highlights with a day tour visiting Plaza San Martin, Plaza De Armas, the Basilica and Convent of San Francisco and Barranco. Taste some local bites and take in the sights of Peru's beautiful capital.

City sightseeing

Tour Type

Small Group Tour

Age Range

10-100 yrs

Operated in

english

Destinations

Lima

Duration1 day

From

USD 100

USD 97

Saving

USD 3

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Lima Day Tour: City Highlights (half day) - October 2025

No booking fees

Best price guaranteed

This half-day walking tour of Lima's historical centre will immerse you in the culture of the city. See the incredible views from the top of a bell tower, admire stunning colonial architecture, and prepare to be fascinated by this city's history.

City sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

10-100 yrs

Operated in

english

Destinations

Lima

Duration1 day

From

USD 40

USD 39

Saving

USD 1

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Inca Jungle Backpacker Trek to Machu Picchu 3D/2N - October 2025

No booking fees

Best price guaranteed

Embark on a captivating journey through Peru’s highlands and jungles. From exhilarating bike rides down the Malaga High Pass to exploring the awe-inspiring citadel of Machu Picchu, every moment promises adventure and discovery. Traverse ancient paths, engage with vibrant local culture, and immerse in breathtaking landscapes, rounding off each day with authentic Peruvian hospitality.

Active and outdoorAdventure

Tour Type

Small Group Tour

Accommodation

Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Cusco, Machu Picchu, Santa Teres

Cusco, Machu Picchu, Santa Teresa, Aguas Calientes

Duration3 days

From

USD 491

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Patagonia Fjords Cargo Boat 4D/3N (from Puerto Montt) - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable Patagonia adventure, navigating through awe-inspiring fjords aboard a cargo boat from Puerto Montt. This unique tour offers breathtaking views of untouched landscapes, pristine waters, and remote coastal villages. Experience the magic of glaciers, diverse wildlife sightings, and serene seclusion. Perfect for nature enthusiasts and adventure seekers, this journey combines the raw beauty of Patagonia with the authentic charm of maritime life. Witness the wonders of Southern Chile on an extraordinary exploration of natural splendor.

Sailing, yachting and motor boating

Tour Type

Small Group Tour

Accommodation

Ship Cabin

Age Range

18-99 yrs

Operated in

english

Destinations

Puerto Natales, Puerto Montt, Gu

Puerto Natales, Puerto Montt, Gulf Of Penas, Puerto Eden, Patagonia

Duration4 days

From

USD 722

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Lake Titicaca & Isla del Sol Adventure 3D/2N (La Paz to La Paz) - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable Bolivian adventure exploring the stunning Lake Titicaca and the mystical Isla del Sol, starting and ending in vibrant La Paz. Experience breathtaking landscapes, immerse in rich indigenous cultures, and witness the awe-inspiring sunrise over the sacred lake. Highlights include guided explorations of ancient ruins, traditional boat rides, and interactions with local communities. Perfect for nature enthusiasts and cultural explorers seeking an authentic and enriching travel experience in South America's heart.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

La Paz, Copacabana, Isla Del Sol

Duration3 days

From

USD 411

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Iguazu Falls Adventure 4D/3N (Puerto to Foz) - October 2025

No booking fees

Best price guaranteed

Embark on an exhilarating Iguazu Falls adventure, immersing yourself in the awe-inspiring beauty of both the Argentine and Brazilian sides. This remarkable tour offers guided excursions through lush rainforests, up-close encounters with powerful cascades, and breathtaking panoramic views. Stay in comfortable accommodations and enjoy convenient transfers. Experience the magic of the world's largest waterfall system, marvel at diverse wildlife, and savor unforgettable moments on this thrilling South American escapade. Perfect for nature lovers and thrill-seekers alike!

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hotel, Hostel

Age Range

18-99 yrs

Operated in

english

Destinations

Foz Do Iguacu, Puerto Iguazu

Duration4 days

From

USD 509

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Uyuni Salt Flats & Desert Adventure 4D/3N (La Paz to Atacama) - October 2025

No booking fees

Best price guaranteed

Embark on a mesmerising 3-day exploration of Bolivia's surreal landscapes. From the eerie beauty of the Train Cemetery to the vivid hues of the coloured lagoons, discover natural wonders and cultural treasures across the Uyuni Salt Flats and the breathtaking Andean highlands. Stay in unique accommodations like the Hotel de Sal, wholly constructed from salt, as you journey through this captivating terrain.

Adventure

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

La Paz, La Paz, San Pedro De Ata

La Paz, La Paz, San Pedro De Atacama, Uyuni, San Juan, Refugio Huayllajara

Duration4 days

From

USD 421

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Ushuaia to Santiago (Ruta 40) Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable Patagonian adventure from snow-capped Ushuaia to vibrant Santiago along iconic Ruta 40. Discover pristine landscapes, immersive cultural encounters, and thrilling outdoor activities. Highlights include exploring the picturesque Glacier National Park, hiking in stunning El Chaltén, and marveling at the surreal Atacama Desert. Dive into local Argentine and Chilean traditions while indulging in exceptional gastronomy. Experience the ultimate South American journey with diverse terrains, breathtaking vistas, and memorable moments tailored for adventurous travelers.

Active and outdoor

Tour Type

Group Tour

Accommodation

Hotel, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Santiago, Ushuaia, Pucon, El Cal

Santiago, Ushuaia, Pucon, El Calafate, El Chalten, Perito Moreno Glacier, San Carlos de Bariloche, Puerto Varas

Duration12 days

From

USD 1,394

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Lima to Buenos Aires (via Pantanal) Travel Pass - October 2025

No booking fees

Best price guaranteed

Embark on the ultimate South American adventure with Bamba’s epic journey from Peru to Argentina. Traverse iconic landscapes, from the Andean peaks to the lush Pantanal wetlands, and experience vibrant cultures in cities like Lima, Buenos Aires, and Rio de Janeiro. Highlights include Machu Picchu, the Uyuni Salt Flats, and Iguazu Falls. Perfect for backpackers and thrill-seekers, this travel pass offers flexible itineraries and unforgettable memories. Immerse yourself in nature, history, and lively local experiences.

Trekking and Hiking

Tour Type

Group Tour

Accommodation

Hostel, Hut, Home-stay, Bungalow, Hotel, Lodge

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Lima, Paracas, Naz

Buenos Aires, Lima, Paracas, Nazca, Cusco, Luquina, Puno, Copacabana, La Paz, Huacachina, Candelaria, Polques, Uyuni, Potosi, Sucre, Santa Cruz, Puerto Quijarro, Corumba, Pantanal, Bonito, Campo Grande, Foz Do Iguacu, Puerto Iguazu, Colca Canyon, Ballestas Islands and Paracas National Reserve

Duration42 days

From

USD 3,710

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Torres del Paine W Express Trek 4D/3N (Self-Guided) - October 2025

No booking fees

Best price guaranteed

Embark on an unforgettable self-guided adventure through Patagonia with exhilarating hikes, breathtaking views of the iconic Torres del Paine, and pristine natural beauty. Discover scenic trails, stunning glaciers, and diverse wildlife in this immersive trekking experience. Perfect for nature enthusiasts, this trek promises awe-inspiring landscapes, serene lakes, and the chance to explore one of the world's most famous national parks. Revel in the freedom of independent exploration while reconnecting with nature's grandeur.

Trekking and HikingAdventure

Tour Type

Small Group Tour

Accommodation

Camping, Hostel, Tent

Age Range

18-99 yrs

Operated in

english

Destinations

Puerto Natales, Patagonia, Torres Del Paine

Duration4 days

From

USD 1,729

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Santiago Sightseeing Classic City Tour - October 2025

No booking fees

Best price guaranteed

This fascinating tour begins with hotel pick-up, followed by a drive down the main avenue of the city as we explore its history and key landmarks. We will start with a panoramic visit to the Central Market, where you can admire the architecture of the place and learn a bit more about its history. Next, we will head to Plaza de Armas, the heart of the city, where we can admire the impressive Santiago Cathedral with its colonial architecture. However, it is possible that the cathedral may be closed for a special event or activity. We will then continue with a walk to the Palacio de la Moneda, the seat of the Chilean government, and Plaza de la Constitución, where we will learn more about Chile's history and its institutions. Depending on the month and day, it is possible to witness the Changing of the Guard, a solemn event that regularly takes place, but this stop may be omitted due to internal activities at the Palacio de la Moneda. We will then head to Cerro Santa Lucía, one of the most iconic hills of the city, where we will stop for a short walk and enjoy panoramic views of Santiago. Our tour continues with a panoramic visit of the iconic Lastarría and Bellavista neighborhoods, known for their cultural offerings, cuisine, and art, giving us a panoramic view of local life. It is a perfect spot to soak in the atmosphere of Santiago and its historic charm. Next, we will visit Parque Bicentenario, a beautiful green space, where you will have time for a relaxing walk in a natural environment. Optionally, if preferred by the passengers, a visit to Bluestone, a lapis lazuli store, the national stone of Chile, can be arranged, where we can admire and/or purchase beautiful jewelry and local crafts. The tour will end with a drop-off at the hotel, the entrance to Cerro San Cristóbal, or at Patio Bellavista.

Sightseeing Tours

Tour Type

Group Tour

Accommodation

Hotel

Age Range

1-79 yrs

Operated in

english, portuguese, spanish

Destinations

Santiago

Duration3 hours

From

USD 64

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Machu Picchu by Train Independent Adventure - Upgraded - October 2025

(2 reviews )

No booking fees

Best price guaranteed

Just do it! The best way to travel

Train toursCulture

Tour Type

Group Tour

Accommodation

Hotel

Age Range

12-100 yrs

Operated in

english

Destinations

Cusco, Machu Picchu

Duration3 days

From

USD 959

USD 930

Saving

USD 29

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Galapagos Affordable 8 Days Tour - October 2025

(1 review )

Trip customizable

Best price guaranteed

A prime destination for wildlife viewing, the Galapagos Islands are on most people's bucket list destinations. Join us on this 'Galapagos Affordable 8 Days Tour' to explore this vaunted archipelago and its wildlife, many of which are found only in the Galapagos. Get to know more about this paradise that inspire Charles Darwin's theory of evolution by natural selection. Led by expert guides, see and learn about the unique bird, animal and marine species, including the giant tortoise, marine iguana, Darwin's finches, lava lizard, flightless cormorant, and Galapagos fur seal. The tour starts and ends in Guayaquil, taking you through several islands of the Galapagos, such as San Cristobal, Satna Cruz, and Isabela. Besides meeting the famous inhabitants of the Galapagos, you will also be taking part in various fun activities like swimming, snorkeling and volcano hiking. And if that's not enough, we also offer various optional activities and excursions for you to choose from. For further details, please go through the itinerary section below.

SnorkelingMarine wildlife

Tour Type

Small Group Tour

Age Range

8-79 yrs

Operated in

english, spanish

Destinations

Galapagos Islands, Guayaquil, Sa

Galapagos Islands, Guayaquil, San Cristobal Island, Isla Santa Cruz, Isabela Island, Bartolome Island, Baltra Island, Quito

Duration8 days

From

USD 2,150

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All South America Tours in October 2025

Page 21 of 517 Trips in South America during October 2025 with 1,020 Reviews

Cusco Day Tour: Humantay Lagoon Hike (full day) - October 2025

Lima Day Tour: Highlights and Insiders Tour (full day) - October 2025

Lima Day Tour: City Highlights (half day) - October 2025

Inca Jungle Backpacker Trek to Machu Picchu 3D/2N - October 2025

Patagonia Fjords Cargo Boat 4D/3N (from Puerto Montt) - October 2025

Lake Titicaca & Isla del Sol Adventure 3D/2N (La Paz to La Paz) - October 2025

Iguazu Falls Adventure 4D/3N (Puerto to Foz) - October 2025

Uyuni Salt Flats & Desert Adventure 4D/3N (La Paz to Atacama) - October 2025

Ushuaia to Santiago (Ruta 40) Travel Pass - October 2025

Lima to Buenos Aires (via Pantanal) Travel Pass - October 2025

Torres del Paine W Express Trek 4D/3N (Self-Guided) - October 2025

Santiago Sightseeing Classic City Tour - October 2025

Machu Picchu by Train Independent Adventure - Upgraded - October 2025

Galapagos Affordable 8 Days Tour - October 2025

Page 21 of 517 Trips in South America during October 2025 with 1,020 Reviews

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Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All South America Tours in October 2025

Page 21 of 517 Trips in South America during October 2025 with 1,020 Reviews

Page 21 of 517 Trips in South America during October 2025 with 1,020 Reviews