South America in 14 Days: 3 Recommended 14-day Itineraries to South America

Need a little more encouragement? Check out our recommended South America 14-day itinerary ideas.

Embark on a 14-day journey through the heart of South America, beginning in the vibrant city of Rio de Janeiro with its famous beaches and samba rhythms. Witness the awe-inspiring Iguazu Falls from both the Brazilian and Argentinian sides, before delving into the passionate streets of Buenos Aires, where tango and culture thrive. Discover Lima's rich history and culinary delights, then venture into Peru's Sacred Valley, culminating in the breathtaking ancient city of Machu Picchu. This itinerary blends natural wonders, cultural immersion, and unforgettable adventures across Brazil, Argentina, and Peru.See all 2-week adventures in South America.

Begin this 14-day South American itinerary plan in the Peruvian Andes, the heart of Incan civilization. Hike the Inca Trail or explore the Sacred Valley's highlights like Pisac Market, Moray Terraces, Ollantaytambo, and Maras Salt Mines. Reach Machu Picchu by train; we suggest the legendary and luxurious Hiram Bingham. Next, head to Buenos Aires, the "Paris of the South." Visit the Casa Rosada, Evita's resting place, and the vibrant neighborhoods of San Telmo and La Boca. Don’t miss a tango show here! Then spend a day exploring Tigre Delta before flying to El Calafate, home to the awe-inspiring Perito Moreno Glacier. Explore the rugged beauty of Los Glaciares National Park, see awe-inspiring glaciers upclose and trek through pristine forests. This itinerary is perfect for those looking for a perfect blend of nature, culture and adventure. See all tours to Argentina and Peru.

Embark on an unforgettable South American adventure, starting in the mesmerizing Atacama Desert of Chile. Explore the dramatic landscapes of salt flats and colorful rock formations before crossing into Bolivia to witness the awe-inspiring Salar de Uyuni and the Sol de Mañana Geysers. Journey through the unique desert scenery to reach La Paz, where you’ll experience the city’s vibrant culture and stunning vistas. Continue to the serene beauty of Lake Titicaca and the ancient island of Isla del Sol. In Peru, marvel at Cusco’s rich Incan heritage, discover the Sacred Valley, and stand in awe of Machu Picchu, one of the New Seven Wonders of the World. This journey combines natural wonders, historical exploration, and cultural immersion, offering a captivating South American experience from Chile to Peru. 

You can tweak this itinerary or pick one of these tailormade tours to South America to build your own holiday. 

Getting around South America varies greatly depending on when you are and where you plan to go. Major cities are often suitable for exploring on foot, and usually have comprehensive public transportation systems. When traveling longer distances, flying is often the easiest, safest, and fastest, but long-distance buses and car rentals are also options for budget-conscious people or those who like the freedom of a road trip. Guided tours to South America are by far one of the safest and most convenient ways to see the continent, and there are options suited to all interests and budgets. We recommend speaking to a local expert for the smoothest South American journey!

More information:
Argentina in 14 days
Bolivia in 2 weeks
2 weeks in Peru
14 days in Colombia
Patagonia in 2 weeks
How many days to spend in South America
10 days in South America
One week in South America