10 Best Andes Multiday Tours in September 2025

12 Day Buenos Aires, Patagonia and Santiago de Chile - September 2025

Trip customizable

Best price guaranteed

This 12 days package takes you through Argentina & Chile's highlights. You’ll start your tour in Argentina's never-sleeping capital city of Buenos Aires before heading up south to the Patagonia, where you will discover the cities of Bariloche and Puerto Varas. From there, you’ll fly to Santiago de Chile and be marveled by the capital of Chile

City sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-79 yrs

Operated in

english

Destinations

Santiago, San Carlos de Bariloch

Santiago, San Carlos de Bariloche, Puerto Varas, Frutillar, Puerto Montt, Buenos Aires

Duration12 days

From

USD 5,471

View Tour

14-Day Journey through Argentina and Brazil - September 2025

Trip customizable

Best price guaranteed

Begin your journey in captivating Buenos Aires, rich in culture and architecture. Explore El Calafate, home to the renowned Perito Moreno Glacier. Venture north to witness the breathtaking Iguazú Falls from the Brazilian side. Conclude your trip in Rio de Janeiro, where iconic landmarks await your discovery. Experience Argentina and Brazil on this 14-day adventure, with transfers, excursions, and accommodation included

AdventureCity sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, Gu

Buenos Aires, Rio de Janeiro, Guanabara Bay, El Calafate, Foz Do Iguacu, Iguassu National Park, Iguassu National Park

Duration14 days

From

USD 6,080

View Tour

Buenos Aires to Santiago (via Mendoza) Travel Pass - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable journey from Buenos Aires to Santiago, immersing yourself in local culture and breathtaking landscapes. Enjoy wine tasting in Argentina's famed Mendoza region, marvel at the Andes’ majestic beauty, and discover vibrant cities bursting with history, art, and gastronomy. Perfect for adventure seekers and culture enthusiasts, this travel pass offers a seamless blend of city life and scenic wonders. Don't miss this chance to explore South America's most dynamic destinations.

Explorer

Tour Type

Group Tour

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Santiago, Córdoba

Buenos Aires, Santiago, Córdoba, Mendoza

Duration7 days

From

USD 540

View Tour

15-Day Journey Across Argentina & Peru - September 2025

Trip customizable

Best price guaranteed

Begin your journey in captivating Buenos Aires, then explore El Calafate and the renowned Perito Moreno Glacier. Next, visit Lima for the Museo Larco, and journey to Machu Picchu by Vistadome train. Embark on an unforgettable adventure, with transfers, excursions, guides, and accommodations included

AdventureCity sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Cusco, Lima, Machu

Buenos Aires, Cusco, Lima, Machu Picchu, El Tigre, El Calafate, Estancia

Duration15 days

From

USD 8,358

View Tour

Samba & Tango Air-Expedition 14D/13N (from Buenos Aires) - September 2025

No booking fees

Best price guaranteed

Embark on an exhilarating South American adventure with an exclusive air-expedition that takes you from Buenos Aires to the heart of Brazil and Argentina. Experience the vibrant cultures of Samba and Tango as you explore iconic landmarks, indulge in local cuisines, and immerse yourself in rich traditions. Highlights include scenic helicopter flights over Iguazu Falls, guided tours of Rio de Janeiro, and captivating dance performances. Perfect for culture enthusiasts and thrill-seekers, this journey guarantees unforgettable memories.

AdventureWalking tours

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, Il

Buenos Aires, Rio de Janeiro, Ilha Grande, Puerto Iguazu, Foz Do Iguacu, Paraty

Duration14 days

From

USD 5,647

View Tour

11-Day Argentina & Peru Essential Tour - September 2025

Trip customizable

Best price guaranteed

Embark on an unforgettable adventure as we explore the enchanting cities of Buenos Aires, Lima, Cusco, and the awe-inspiring Machu Picchu during an immersive 11-day / 10-night journey. Don't let this opportunity slip away! Our "Essential Argentina and Perú" travel package includes accommodation, airport transfers and excursions

Trekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Cusco, Ollantaytam

Buenos Aires, Cusco, Ollantaytambo, Lima

Duration11 days

From

USD 5,535

View Tour

8-Day Argentina & Patagonia Tour From Buenos Aires: El Calafate & Ushuaia - September 2025

Trip customizable

Best price guaranteed

Embark on a Patagonian adventure, starting with 1 night in Buenos Aires to explore the city. Then, spend 3 nights each in El Calafate and Ushuaia. Discover the wild beauty of Patagonia, with its snowy peaks, scenic lakes, and captivating beaver dams. Tour the heart of Los Glaciares National Park for an unforgettable experience

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Tierra Del Fuego

Buenos Aires, Tierra Del Fuego, El Calafate, Perito Moreno Glacier, Ushuaia, Escondido

Duration8 days

From

USD 4,024

View Tour

12 Day Argentina & Brazil - September 2025

Trip customizable

Best price guaranteed

This packed 12 days tour takes you through Argentina & Brazil highlights. You’ll start your tour in Argentinas never-sleeping capital city of Buenos Aires before heading up north to Puerto Iguazu, where you will find the amazing Iguazú Falls on the borders of Brazil and Paraguay. From there you’ll fly to Rio de Janeiro and be marveled by its incredible beaches

Explorer

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Buenos Aires, Rio de Janeiro, An

Buenos Aires, Rio de Janeiro, Angra Dos Reis, Colonia, Puerto Iguazu, Iguazu Falls, Iguazu Falls

Duration12 days

From

USD 4,838

View Tour

4-Day Ushuaia Tour - September 2025

Trip customizable

Best price guaranteed

Enjoy Ushuaia with this 4-day/3-night Vacation Package that includes the main tourist attractions of Ushuaia and its surroundings. We offer roundtrip transfers between the airport and your hotel, as well as during the tours. An expert guide will be by your side for both the tours to Tierra del Fuego National Park and the scenic boat ride. Additionally, we have taken care of your accommodation at a comfortable 4-star hotel, where you'll enjoy a stay in a Standard room complete with a delicious breakfast to start your day

Natural landmarks sightseeing

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

1-99 yrs

Operated in

english

Destinations

Tierra Del Fuego, Ushuaia

Duration4 days

From

USD 1,272

View Tour

Uyuni Salt Flats & Desert Adventure 4D/3N (Atacama to Atacama) - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable journey from the Atacama Desert to Bolivia’s Uyuni Salt Flats, renowned as the world's largest salt flat. This adventure includes stunning landscapes, geothermal wonders, and vibrant lagoons brimming with flamingos. Travel through surreal rock formations and pristine deserts, capturing breathtaking sunset reflections on the salt flats. Ideal for nature enthusiasts and photographers, this expedition offers an immersive experience in one of South America’s most iconic and picturesque regions. Join this extraordinary tour today!

Desert safaris

Tour Type

Small Group Tour

Accommodation

Hotel, Hostel, Villa

Age Range

18-99 yrs

Operated in

english

Destinations

Uyuni, San Pedro De Atacama, Lag

Uyuni, San Pedro De Atacama, Laguna Colorada, Chiguana Salt Flat, Villamar Mallcu

Duration4 days

From

USD 414

View Tour

Patagonia: the Ultimate Adventure - September 2025

4.8

(20 reviews )

Trip customizable

Best price guaranteed

Antonella and Helena made planning our dream Patagonia trip such a great experience! They made sure we got the best possible plans and also helped us through our visa processes which would have been impossible task without their constant support! We highly recommend letting Say Hueque plan your trip- days in Patagonia can be very hectic and having transfers, accommodations, tickets etc reserved for you makes everything a lot easier and seamless and allows you to enjoy the place without sweating the small stuff…Antonella and Helena made that possible for us! We’re so do grateful for this beautiful vacay and we’re 100% going to be back for more!!!

Sightseeing ToursAdventure

Tour Type

Private Tour

Accommodation

Hotel

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

El Calafate, Torres del Paine Na

El Calafate, Torres del Paine National Park, Perito Moreno Glacier

Duration5 days

From

USD 960

View Tour

Adventure in Iguazu - 2 nights - September 2025

Trip customizable

Best price guaranteed

This tour is a 2-night program to visit Iguazu Falls, one of the most incredible places in the world! The program includes a visit to two different national parks, one in Argentina and the other one in Brazil. The Argentinian Park offers up to 8 kilometres of trails to enjoy the falls in three different circuits: Upper circuit, Lower circuit and trail to the Devil´s Throat. We will also undertake some great adventure activities in the jungle, including riding a 4x4 truck, hiking and a boat navigation to enjoy the falls from the river. On the Brazilian side is a 1500-meter trail on which we can enjoy a wonderful panoramic view of the falls. The best part? The tour includes a helicopter flight to enjoy the falls from the sky! Are you ready?

Natural landmarks sightseeing

Tour Type

Group Tour

Accommodation

Hotel

Age Range

5-79 yrs

Operated in

english, spanish

Destinations

Iguazu Falls, Iguazu Falls

Duration3 days

From

USD 590

View Tour

Lake Titicaca & Isla del Sol Explorer 3D/2N (La Paz to Cuzco) - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable adventure exploring Lake Titicaca and the enchanting Isla del Sol. This journey offers breathtaking views, rich cultural experiences, and hands-on adventures. Highlights include boat rides on the world's highest navigable lake, ancient Inca ruins, and immersive interactions with local communities. Wander through Bolivia's cultural hubs and Peru's scenic landscapes, perfect for travelers seeking both relaxation and thrilling exploration. Enhance your South American odyssey with this unique and scenic travel experience. Secure your spot now and delve into the mystical beauty of the Andes.

AdventureExplorer

Tour Type

Small Group Tour

Accommodation

Hostel, Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Cusco, La Paz, La Paz, Isla Del Sol

Duration3 days

From

USD 155

View Tour

Uyuni Salt Flats & Desert Adventure 3D/2N (Atacama to Uyuni) - September 2025

No booking fees

Best price guaranteed

Embark on an unforgettable journey through the mesmerizing Uyuni Salt Flats, a photographer's dream destination. Explore surreal landscapes, including vibrant desert lagoons, towering volcanoes, and the captivating Train Graveyard. Encounter unique wildlife at Eduardo Avaroa National Reserve, and experience authentic Bolivian culture as you traverse this otherworldly terrain. This adventure offers exclusive guided tours, stunning sunrise and sunset vistas, and immersive experiences that make it a must-do for nature lovers and thrill-seekers. Book now for an unparalleled Atacama adventure!

ExplorerAdventure

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

18-99 yrs

Operated in

english

Destinations

Uyuni, Atacama Desert, San Pedro

Uyuni, Atacama Desert, San Pedro De Atacama, Uyuni Salt Flat

Duration3 days

From

USD 359

View Tour

All Andes Tours in September 2025

Page 3 of 749 Trips in Andes during September 2025 with 417 Reviews

12 Day Buenos Aires, Patagonia and Santiago de Chile - September 2025

14-Day Journey through Argentina and Brazil - September 2025

Buenos Aires to Santiago (via Mendoza) Travel Pass - September 2025

15-Day Journey Across Argentina & Peru - September 2025

Samba & Tango Air-Expedition 14D/13N (from Buenos Aires) - September 2025

11-Day Argentina & Peru Essential Tour - September 2025

8-Day Argentina & Patagonia Tour From Buenos Aires: El Calafate & Ushuaia - September 2025

12 Day Argentina & Brazil - September 2025

4-Day Ushuaia Tour - September 2025

Uyuni Salt Flats & Desert Adventure 4D/3N (Atacama to Atacama) - September 2025

Patagonia: the Ultimate Adventure - September 2025

Adventure in Iguazu - 2 nights - September 2025

Lake Titicaca & Isla del Sol Explorer 3D/2N (La Paz to Cuzco) - September 2025

Uyuni Salt Flats & Desert Adventure 3D/2N (Atacama to Uyuni) - September 2025

Page 3 of 749 Trips in Andes during September 2025 with 417 Reviews

Europe

Asia

South America

Africa

North America

Oceania

Polar

Food, wine, events and nightlife

Adventure and sport

Wildlife, landscapes and nature

Boat tours, water sports and marine wildlife

Sightseeing, attractions, culture and history

Air tours, road trips and transfers

Beach, romance, getaways and relaxation

Special interests and hobbies

All Andes Tours in September 2025

Page 3 of 749 Trips in Andes during September 2025 with 417 Reviews

Page 3 of 749 Trips in Andes during September 2025 with 417 Reviews