21-Day South America Tours - Unique 21-Day tours to South America

Accommodations

BudgetSimple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Mid-rangeComfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
PremiumUpscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.

Southern Divide - 21 days

(8 reviews )

No booking fees

Best price guaranteed

Lima and Santiago bookended this trip. The small cities and towns we visited were more to my taste. La Paz was special in part because of a very good city tour largely on the cable card.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel, Resort, Guest House

Age Range

12-100 yrs

Operated in

english

Destinations

Santiago, Lima, La Paz, Sucre, P

Santiago, Lima, La Paz, Sucre, Potosi, Uyuni, Salar De Uyuni, San Pedro De Atacama, Cusco, Ollantaytambo, Aguas Calientes, Puno

Duration21 days

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Lima to La Paz: Sandboarding & Sunsets - 21 days

4.9

(10 reviews )

No booking fees

Best price guaranteed

Travelling from Lima to La Paz was an experience I will never forget. It was a great way to experience for the most part what the country has to offer including local delicacies, nature/wildlife , culture and soo much more.

Trekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hotel, Home-stay, Camping, Hostel

Age Range

18-39 yrs

Operated in

english

Destinations

Lima, La Paz, Cusco, Ollantaytam

Lima, La Paz, Cusco, Ollantaytambo, Llactapata, Dead Woman's Pass, Wiñay Wayna, Puno, Lake Titicaca, Huacachina, Nazca, Arequipa, Colca Canyon

Duration21 days

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Falklands, South Georgia and Antarctica - Expedition - 21 days

(2 reviews )

No booking fees

Best price guaranteed

Booked through Explore but the Expedition was through G Adventures.

Polar expeditions and cruise

Tour Type

Small Group Tour

Accommodation

Hotel, Resort, Ship Cabin

Age Range

16-79 yrs

Operated in

english

Destinations

Ushuaia, South Shetland Islands

Ushuaia, South Shetland Islands, South Georgia, At Sea, Falkland Island, Drake Passage

Duration21 days

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Falklands, South Georgia and Antarctica - M/V Sylvia Earle - 21 days

(1 review )

No booking fees

Best price guaranteed

Fantastic ship, group leaders and ship personnel. Awesome scenery and a genuine adventure. Would love to do another trip on this vessel with Aurora.

Polar expeditions and cruise

Tour Type

Small Group Tour

Accommodation

Hotel, Hut, Ship Cabin

Age Range

16-79 yrs

Operated in

english

Destinations

Ushuaia, Antarctic Peninsula, So

Ushuaia, Antarctic Peninsula, South Georgia, At Sea, Drake Passage

Duration21 days

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Absolute Peru - 21 days

(9 reviews )

No booking fees

Best price guaranteed

The 21 day adventure exceeded my expectations. It provided a wonderful introduction to the history and diversity of Peru’s culture. The hike to Machu Picchu was, in places, challenging but imminently doable. The tour leaders were knowledgeable, friendly, engaging and interesting people. My desire to participate in another G Adventures tour is driven in large part by the quality of their tour leaders.

WildlifeTrekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hotel, Home-stay, Guest House, Camping

Age Range

12-100 yrs

Operated in

english

Destinations

Lima, Cusco, Ollantaytambo, Agua

Lima, Cusco, Ollantaytambo, Aguas Calientes, Tambopata Reserve, Paracas, Nazca, Arequipa, Colca Canyon, Puno, Lake Titicaca

Duration21 days

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Peru Essentials - 21 days

No booking fees

Best price guaranteed

If you're seeking an immersive trekking adventure through the heart of Peru and Bolivia, the "Peru Essentials" tour delivers a 21-day journey packed with cultural intrigue and breathtaking landscapes. Setting out from Lima, this challenging trip is perfectly suited for active travelers ready to hike ancient trade routes, including the iconic Inca Trail, culminating at the legendary Machu Picchu. Along the way, you’ll marvel at the soaring condors of Colca Canyon, explore the mysterious Nazca lines, and soak up local traditions on Lake Titicaca’s floating islands. The tour also ventures into Bolivia, concluding in La Paz, giving you a rare opportunity to experience two vibrant countries in one seamless package. With guidance from a knowledgeable local leader, plus plenty of flexibility to personalize your itinerary, this tour package stands out for its expertly balanced blend of guided exploration and independence—making it ideal for those who crave both structure and adventure. Accommodation, transport, and meals are all provided, so you can focus on trekking, hiking, and soaking in the diverse wonders of South America.

Trekking and Hiking

Tour Type

Small Group Tour

Accommodation

Hotel, Camping, Home-stay

Age Range

15-99 yrs

Operated in

english

Destinations

Lima, La Paz, Cusco, Inca Trail

Lima, La Paz, Cusco, Inca Trail, Puno, Ballestas Islands and Paracas National Reserve, Nazca, Arequipa, Colca Canyon

Duration21 days

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Best of Peru, Argentina & Brazil - 21 days

No booking fees

Best price guaranteed

Unveil the spirit of South America on this 21-day journey through Peru, Argentina, and Brazil—a region bursting with energy, color, and history. Starting in Lima and ending in Rio de Janeiro, the tour weaves through the ancient Inca heartlands, Argentina’s enigmatic cities, and the pulsating rhythms of Brazil. You’ll marvel at Machu Picchu, stroll through vibrant markets and jungles, and experience Rio’s infectious dynamism. Along the way, local encounters and wildlife sightings offer insights into the diversity of this remarkable continent. With an easy pace and guided exploration, the unique selling point of this trip is its comprehensive sweep across three iconic countries—inviting you to experience South America’s captivating contrasts in a single, memorable tour package.

Cultural, religious and historic sites

Tour Type

Small Group Tour

Accommodation

Hotel

Age Range

15-99 yrs

Operated in

english

Destinations

Rio de Janeiro, Lima, Sacred Val

Rio de Janeiro, Lima, Sacred Valley, Aguas Calientes, Cusco, Buenos Aires, Foz Do Iguazu, Foz Do Iguacu, Paracas, Nazca, Arequipa, Puno

Duration21 days

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Peru & Bolivia Encounter - 21 days

No booking fees

Best price guaranteed

Explore South America's salt flats, ancient deserts, geysers and valleys on this 21-day adventure from Lima to San Pedro De Atacama. Ride the teleferico (cable car) over the world’s tallest capital city (La Paz), explore the Andrean Desert and travel across the Uyuni Salt Flats with a local leader by your side. Learn about ancient rock carvings at Yerbas Buenas, discover the diverse ecology in the depths of the Amazon and journey around the islands of Lake Titicaca. See flamingo-filled lagoons and lunar valleys as you cross into the Atacama Desert, watch the sun rise over Rainbow Canyon and indulge in Bolivian and Chilean cuisine every step of the way.

Explorer

Tour Type

Small Group Tour

Accommodation

Camping, Eco Lodge, Hotel, Lodge

Age Range

15-99 yrs

Operated in

english

Destinations

Lima, San Pedro De Atacama, Cusc

Lima, San Pedro De Atacama, Cusco, Puno, Lake Titicaca, La Paz, Uyuni, Silolio Dykuma, Amazon Jungle, Ollantaytambo, Inca Trail

Duration21 days

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Mountains to the Lakes - 21 days

Trip customizable

Best price guaranteed

This comprehensive 3 week tour is designed to reveal some of the secrets lying in South America. The tour begins in Lima; you then head south for an incredible Ballestas Islands boat trip where you will see exotic birds and sea mammals. You then travel inland to the desert and the palm trees and sand dunes of the Oasis of Huacachina where we make camp under the stars. You will then visit the mysterious Nazca lines whose true meaning is still up for debate. The tour then starts it's ascent into the Andes to the town of Arequipa and the Colca Canyon, the deepest in the world. The tour then takes us to Cuzco where we prepare for the unforgettable Inca Trail, after reaching Machu Picchu we head back to Cuzco for some relaxing time in this beautiful Andean city. We continue our journey to Lake Titicaca where we spend time learning of the traditions of the local Uros Indians, with free time to laze the day away on the shores of this deep blue lake. The tour makes it's final stop in La Paz, giving you free time to explore the Bolivian capital.

Mountains

Tour Type

Small Group Tour

Accommodation

Hotel, Camping, Guest House, Home-stay

Age Range

16-85 yrs

Operated in

english

Destinations

Lima, La Paz, Inca Trail, Machu

Lima, La Paz, Inca Trail, Machu Picchu, Cusco, Puno, Copacabana, Ballestas Islands and Paracas National Reserve, Huacachina, Nazca Lines, Arequipa

Duration21 days

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Galapagos Cruise & Peru’s Land of the Incas (Grand Daphne) - 21 days

No booking fees

Best price guaranteed

Begin in Quito and end in La Paz on the Galapagos Cruise & Peru’s Land of the Incas (Grand Daphne)—a 21-day odyssey across Ecuador, Peru, and Bolivia. Glide past flamingos on Isla Floreana, sunbathe with sea lions on Gardner Beach, and snorkel with turtles and rays. Then, shift gears to explore Peru’s and Bolivia’s highlands: trek through the Sacred Valley, walk the cobbled streets of Cusco, and venture into the Amazon Jungle. Enjoy a homestay on Lake Titicaca and choose to see Machu Picchu by trek or scenic train. With its challenging activity level, this tour is made for adventurous travelers who crave active, in-depth exploration. The USP is its rare combination of Galapagos island-hopping and immersive Andean and Amazonian cultural experiences, catering to those seeking variety and depth in their journey.

ExplorerCruise

Tour Type

Small Group Tour

Accommodation

Ship Cabin, Camping, Eco Lodge, Home-stay, Hotel, Lodge

Age Range

15-99 yrs

Operated in

english

Destinations

Quito, La Paz, Cusco, Ollantayta

Quito, La Paz, Cusco, Ollantaytambo, Inca Trail, Puno, Isla Santa Cruz, Floreana Island, Espanola Island, Lima, Amazon Jungle

Duration21 days

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South America 21-Day Tours and Trips

The Best 21-day Trips in South America with 30 Reviews

Southern Divide - 21 days

Lima to La Paz: Sandboarding & Sunsets - 21 days

The Best 21-day Trips in South America with 30 Reviews

Falklands, South Georgia and Antarctica - Expedition - 21 days

Falklands, South Georgia and Antarctica - M/V Sylvia Earle - 21 days

Absolute Peru - 21 days

Peru Essentials - 21 days

Best of Peru, Argentina & Brazil - 21 days

Peru & Bolivia Encounter - 21 days

Mountains to the Lakes - 21 days

Galapagos Cruise & Peru’s Land of the Incas (Grand Daphne) - 21 days

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South America 21-Day Tours and Trips

The Best 21-day Trips in South America with 30 Reviews

The Best 21-day Trips in South America with 30 Reviews