Discover the best 21-Day tours in South America with Bookmundi. We offer a total of 10 South America 21-Day tours and itineraries with 20 customer reviews.
Simple stays with essential amenities. Typically guesthouses, hostels or hotels rated below 3 stars — clean, no-frills, and great for value-conscious travelers.
Comfortable and reliable 3-star stays. Expect private rooms, en-suite bathrooms, and solid amenities — a great balance between comfort and cost.
Upscale 4-5 star hotels and lodges. Enjoy high-end service, refined comfort, and premium locations — ideal for travelers seeking extra indulgence.
Destinations
Guide Types
Start & End Location
Price
USD 1,662USD 20,776
Showing 1 - 10 of 13 results
The Best 21-day Trips in South America with 27 Reviews
Lima and Santiago bookended this trip. The small cities and towns we visited were more to my taste. La Paz was special in part because of a very good city tour largely on the cable card.
Cultural, religious and historic sites
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Accommodation
Hotel, Resort, Guest House
Age Range
12-100 yrs
Operated in
english
Destinations
Santiago, Lima, La Paz, Sucre, P
Santiago, Lima, La Paz, Sucre, Potosi, Uyuni, Salar De Uyuni, San Pedro De Atacama, Cusco, Ollantaytambo, Aguas Calientes, Puno
Travelling from Lima to La Paz was an experience I will never forget. It was a great way to experience for the most part what the country has to offer including local delicacies, nature/wildlife , culture and soo much more.
Trekking and Hiking
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Accommodation
Hotel, Home-stay, Camping, Hostel
Age Range
18-39 yrs
Operated in
english
Destinations
Lima, La Paz, Cusco, Ollantaytam
Lima, La Paz, Cusco, Ollantaytambo, Llactapata, Dead Woman's Pass, Wiñay Wayna, Puno, Lake Titicaca, Huacachina, Nazca, Arequipa, Colca Canyon
The 21 day adventure exceeded my expectations. It provided a wonderful introduction to the history and diversity of Peru’s culture. The hike to Machu Picchu was, in places, challenging but imminently doable. The tour leaders were knowledgeable, friendly, engaging and interesting people.
My desire to participate in another G Adventures tour is driven in large part by the quality of their tour leaders.
WildlifeTrekking and Hiking
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Unveil the spirit of South America on this 21-day journey through Peru, Argentina, and Brazil—a region bursting with energy, color, and history. Starting in Lima and ending in Rio de Janeiro, the tour weaves through the ancient Inca heartlands, Argentina’s enigmatic cities, and the pulsating rhythms of Brazil.
You’ll marvel at Machu Picchu, stroll through vibrant markets and jungles, and experience Rio’s infectious dynamism. Along the way, local encounters and wildlife sightings offer insights into the diversity of this remarkable continent.
With an easy pace and guided exploration, the unique selling point of this trip is its comprehensive sweep across three iconic countries—inviting you to experience South America’s captivating contrasts in a single, memorable tour package.
Cultural, religious and historic sites
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Accommodation
Hotel
Age Range
15-99 yrs
Operated in
english
Destinations
Rio de Janeiro, Lima, Sacred Val
Rio de Janeiro, Lima, Sacred Valley, Aguas Calientes, Cusco, Buenos Aires, Foz Do Iguazu, Foz Do Iguacu, Paracas, Nazca, Arequipa, Puno
Unveil the diverse tapestry of South America on the Highlights of South America – 21 days, an easy-paced wildlife tour designed for experienced travelers and seniors. This luxurious group journey begins in Rio de Janeiro and winds through Foz Do Iguacu, La Paz, and Lima, with stops at Machu Picchu and the bustling heart of Buenos Aires. Stay in elegant hotels, visit the awe-inspiring Iguazu Falls, ascend to the world’s highest capital, and discover ancient Incan secrets. With accommodation, transport, and meals included, every detail is handled for you. The USP? A seamless, high-comfort trip through four countries, blending natural wonders, cultural treasures, and the thrill of Machu Picchu in one unforgettable package.
Wildlife
Tour Type
Group Tour
Accommodation
Hotel, Luxury Hotel
Age Range
18-80 yrs
Operated in
english
Destinations
Rio de Janeiro, Lima, La Paz, Co
Rio de Janeiro, Lima, La Paz, Copacabana, Puno, Cusco, Foz Do Iguacu, Buenos Aires, Sucre
This comprehensive 3 week tour is designed to reveal some of the secrets lying in South America. The tour begins in Lima; you then head south for an incredible Ballestas Islands boat trip where you will see exotic birds and sea mammals. You then travel inland to the desert and the palm trees and sand dunes of the Oasis of Huacachina where we make camp under the stars. You will then visit the mysterious Nazca lines whose true meaning is still up for debate. The tour then starts it's ascent into the Andes to the town of Arequipa and the Colca Canyon, the deepest in the world. The tour then takes us to Cuzco where we prepare for the unforgettable Inca Trail, after reaching Machu Picchu we head back to Cuzco for some relaxing time in this beautiful Andean city. We continue our journey to Lake Titicaca where we spend time learning of the traditions of the local Uros Indians, with free time to laze the day away on the shores of this deep blue lake. The tour makes it's final stop in La Paz, giving you free time to explore the Bolivian capital.
Mountains
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Accommodation
Hotel, Camping, Guest House, Home-stay
Age Range
16-85 yrs
Operated in
english
Destinations
Lima, La Paz, Inca Trail, Machu
Lima, La Paz, Inca Trail, Machu Picchu, Cusco, Puno, Copacabana, Ballestas Islands and Paracas National Reserve, Huacachina, Nazca Lines, Arequipa
Vast penguin colonies, dramatic coastlines, and the legend of Ernest Shackleton—these are just a few highlights awaiting experienced travelers on the 21-day "Spirit of Shackleton" expedition cruise. Departing from Ushuaia, this awe-inspiring photography tour sails to South Georgia, the Falkland Islands, and the Antarctic Peninsula, revealing the haunting beauty and history of the world’s most remote wilderness. Along the way, you’ll visit historic explorers’ sites and Shackleton’s final resting place, while encountering seals, penguins, and towering icebergs. The USP? This trip offers an unrivaled blend of wildlife encounters and polar history, making it a dream for those seeking a comprehensive Antarctic adventure.
If you're seeking an immersive trekking adventure through the heart of Peru and Bolivia, the "Peru Essentials" tour delivers a 21-day journey packed with cultural intrigue and breathtaking landscapes. Setting out from Lima, this challenging trip is perfectly suited for active travelers ready to hike ancient trade routes, including the iconic Inca Trail, culminating at the legendary Machu Picchu. Along the way, you’ll marvel at the soaring condors of Colca Canyon, explore the mysterious Nazca lines, and soak up local traditions on Lake Titicaca’s floating islands. The tour also ventures into Bolivia, concluding in La Paz, giving you a rare opportunity to experience two vibrant countries in one seamless package. With guidance from a knowledgeable local leader, plus plenty of flexibility to personalize your itinerary, this tour package stands out for its expertly balanced blend of guided exploration and independence—making it ideal for those who crave both structure and adventure. Accommodation, transport, and meals are all provided, so you can focus on trekking, hiking, and soaking in the diverse wonders of South America.
Trekking and Hiking
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Accommodation
Hotel, Camping, Home-stay
Age Range
15-99 yrs
Operated in
english
Destinations
Lima, La Paz, Cusco, Inca Trail
Lima, La Paz, Cusco, Inca Trail, Puno, Ballestas Islands and Paracas National Reserve, Nazca, Arequipa, Colca Canyon
Begin in Quito and end in La Paz on the Galapagos Cruise & Peru’s Land of the Incas (Grand Daphne)—a 21-day odyssey across Ecuador, Peru, and Bolivia. Glide past flamingos on Isla Floreana, sunbathe with sea lions on Gardner Beach, and snorkel with turtles and rays. Then, shift gears to explore Peru’s and Bolivia’s highlands: trek through the Sacred Valley, walk the cobbled streets of Cusco, and venture into the Amazon Jungle. Enjoy a homestay on Lake Titicaca and choose to see Machu Picchu by trek or scenic train. With its challenging activity level, this tour is made for adventurous travelers who crave active, in-depth exploration. The USP is its rare combination of Galapagos island-hopping and immersive Andean and Amazonian cultural experiences, catering to those seeking variety and depth in their journey.
ExplorerCruise
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Explore South America's salt flats, ancient deserts, geysers and valleys on this 21-day adventure from Lima to San Pedro De Atacama. Ride the teleferico (cable car) over the world’s tallest capital city (La Paz), explore the Andrean Desert and travel across the Uyuni Salt Flats with a local leader by your side. Learn about ancient rock carvings at Yerbas Buenas, discover the diverse ecology in the depths of the Amazon and journey around the islands of Lake Titicaca. See flamingo-filled lagoons and lunar valleys as you cross into the Atacama Desert, watch the sun rise over Rainbow Canyon and indulge in Bolivian and Chilean cuisine every step of the way.
Explorer
Tour Type
Small Group TourSmall group tours usually have 8-12 participants and maximum up to 18 travelers
Accommodation
Camping, Eco Lodge, Hotel, Lodge
Age Range
15-99 yrs
Operated in
english
Destinations
Lima, San Pedro De Atacama, Cusc
Lima, San Pedro De Atacama, Cusco, Puno, Lake Titicaca, La Paz, Uyuni, Silolio Dykuma, Amazon Jungle, Ollantaytambo, Inca Trail
